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Title Inhibitors of protein kinases and protein phosphataes / contributors, D.R. Alexander [and others] ; editors, Lorenzo A. Pinna and Patricia T.W. Cohen
Edition 1st ed
Published Berlin ; New York : Springer, 2004


Description 1 online resource (x, 458 pages) : illustrations
Series Handbook of experimental pharmacology ; v. 167
Handbook of experimental pharmacology ; v. 167.
Contents Cover -- Preface -- Table of Contents -- Protein Kinase Inhibitors for the Treatment of Disease: The Promise and the Problems -- Part I. General Aspects of PKs Inhibition -- New Design Strategies for Ligands That Target Protein Kinase-Mediated Protein ... Protein Interactions -- Part II. Pharmacological Potential and Inhibitors of Individual Classes of Protein Kinases -- The Paullones: A Family of Pharmacological Inhibitors of Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 -- Pharmacological Potential of p38 MAPK Inhibitors -- Inhibitors of PKA and Related Protein Kinases -- Inhibitors of Protein Kinase CK2: Structural Aspects -- Aminoglycoside Kinases and Antibiotic Resistance. -- Part III. Pharmacological Potential and Inhibitors of Individual Classes of Protein Phosphatases -- Protein Tyrosine Phosphatases as Therapeutic Targets -- Structure-Based Design of Protein Tyrosine Phosphatase Inhibitors -- Biological Validation of the CD45 Tyrosine Phosphatase as a Pharmaceutical Target -- Serine/Threonine Protein Phosphatase Inhibitors with Antitumor Activity -- Part IV. Inhibitors in Clinical Use or Advanced Clinical Trials -- Clinical Immunosuppression using the Calcineurin-Inhibitors Ciclosporin and Tacrolimus. -- Targeted Therapy with Imatinib: An Exception or a Rule? -- Clinical Aspects of Imatinib Therapy -- Isoquinolinesulfonamide: A Specific Inhibitor of Rho-Kinase and the Clinical Aspect of Anti-Rho-Kinase Therapy -- Discovery and Development of Iressa: The First in a New Class of Drugs Targeted at the Epidermal Growth Factor Receptor Tyrosine Kinase
Summary The aims of this volume are to highlight the tremendous pharmacological potential of protein kinase and protein phosphatase inhibitors, to provide a thorough overview of the most remarkable achievements in the field and to illustrate how beneficial these studies can be for the advancement of both basic knowledge on biological regulation and deregulation and for the clinical treatment of a wide spectrum of diseases. This goal is attained by contributions of leader investigators in the field, who address the issue from different angles
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Subject Protein kinases -- Inhibitors -- Handbooks, manuals, etc
Phosphoprotein phosphatases -- Inhibitors -- Handbooks, manuals, etc
Protein Kinase Inhibitors
Phosphoprotein Phosphatases -- antagonists & inhibitors
Phosphoprotein Phosphatases -- therapeutic use
Protein Kinases -- therapeutic use
MEDICAL -- Pharmacology.
Sciences de la vie.
Protein kinases -- Inhibitors.
Genre/Form Handbooks and manuals.
Handbooks and manuals.
Guides et manuels.
Form Electronic book
Author Pinna, Lorenzo A
Cohen, Patricia T. W
ISBN 3540212426