| Description |
1 online resource (xv, 460 pages) |
| Series |
Subcellular biochemistry, 0306-0225 ; 59 |
|
Sub-cellular biochemistry ; 59.
|
| Contents |
Ca² signalling by IP₃ receptors -- Phosphoinositide signaling during membrane transport -- Phosphoinositides in the mammalian endo-lysosomal network -- Role of PI(4,5)P₂ in vesicle exocytosis and membrane fusion -- Role of phosphoinositides at the neuronal synapse -- Phosphatidylinositol 4,5 bisphosphate and the actin cytoskeleton -- Phosphoinositides in chemotaxis -- Phosphoinositides in golgi complex function -- Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate golgi functionality -- Phosphoinositide sensitivity of ion channels, a functional perspective -- Nuclear phosphoinositides: location, regulation and function -- Phosphoinositides and cellular pathogens -- Defining signal transduction by inositol phosphates -- Cell signalling by inositol pyrophosphates |
| Summary |
Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol |
| Analysis |
Medicine |
|
Human genetics |
|
Medical genetics |
|
Neurosciences |
|
Neurochemistry |
|
Biomedicine |
|
Molecular Medicine |
|
Gene Function |
|
biomedische wetenschappen |
|
neurowetenschap |
|
neuroscience |
|
geneeskunde |
|
humane genetica |
|
neurochemie |
|
moleculaire genetica |
|
molecular genetics |
|
Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| In |
Springer eBooks |
| Subject |
Phosphoinositides.
|
|
Phosphatidylinositols
|
|
medicines (material)
|
|
SCIENCE -- Life Sciences -- Biochemistry.
|
|
Phosphoinositides
|
| Form |
Electronic book
|
| Author |
Balla, Tamas, Dr.
|
|
Wymann, Matthias.
|
|
York, John D.
|
| ISBN |
9789400730151 |
|
9400730152 |
|
9400730144 |
|
9789400730144 |
|
