| Description |
1 online resource (x, 304 pages) : illustrations |
| Series |
Current topics in microbiology and immunology ; v. 347 |
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Current topics in microbiology and immunology ; v. 347.
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| Contents |
880-01 Phosphoinositide 3-kinase in Health and Disease; Volume 2; Contents; Contributors; PI3K: From the Bench to the Clinic and Back; Oncogenic Mutations of PIK3CA in Human Cancers; Structural Effects of Oncogenic PI3Ka Mutations; Comparing the Roles of the p110a and p110beta Isoforms of PI3K in Signaling and Cancer; Phosphatidylinositol 3-Kinase: The Oncoprotein; AKT Signaling in Physiology and Disease; Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse; PI3K as a Target for Therapy in Haematological Malignancies; Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors |
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880-01/(S 3 Mechanisms of Activation of Class IA p110 Isoforms3.1 Early Studies on In Vitro p110α/beta Activation; 3.2 Studies on p110 Activation Using Engineered Mice; 3.3 Unresolved Issues; 4 Downstream Signaling: Acting Out Through AKT and PDK1; 4.1 AKT Signaling; 5 PI3K Isoforms in Cancer; 5.1 Deregulated PI3K Pathway Components; 5.2 Targeting PI3K in Cancer; 5.3 p110α as a Viable Tumor Target; 5.4 p110beta as a Drug Target; 5.5 What Are the Take-Home Messages from p110-Isoform Knock-Out Studies In Vivo; 5.6 Kinase-Independent Roles of p110-Isoforms; 6 Conclusions; References |
| Summary |
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target |
| Analysis |
Pi3k Cancer |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Phosphoinositides -- Physiological effect
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Protein kinases.
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Cellular signal transduction.
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Protein Kinase Inhibitors -- therapeutic use
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Protein Kinases -- physiology
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Signal Transduction
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Protein Kinases
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MEDICAL -- Biochemistry.
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Cellular signal transduction
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Phosphoinositides -- Physiological effect
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Protein kinases
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| Form |
Electronic book
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| Author |
Rommel, Christian
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Vanhaesebroeck, Bart
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Vogt, P. K. (Peter K.), 1932-
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| ISBN |
9783642148163 |
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3642148166 |
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9783642148156 |
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3642148158 |
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