| Description |
1 online resource (ix, 306 pages) : illustrations (some color) |
| Series |
Current topics in microbiology and immunology, 0070-217X ; v. 346 |
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Current topics in microbiology and immunology ; v. 346
|
| Contents |
PI3K -- From the Bench to the Clinic and Back -- PI3K Book Introduction -- PDK1: The major transducer of PI 3-Kinase actions -- Protein Kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway -- Regulatory subunits of class IA PI3K -- The Regulation of Class IA PI 3-kinases by Inter-Subunit Interactions -- Phosphoinositide signalling pathways in metabolic regulation -- Role of RAS in the regulation of PI 3-kinase -- More than just kinases: The scaffolding function of PI3K -- PI3K signalling in neutrophils -- PI 3-kinase p110beta regulation of platelet integrin alphaIIbbeta3 -- PI3Ks in lymphocyte signalling and development -- PI3 kinase regulation of skeletal muscle hypertrophy and atrophy -- Taking PI3Kdelta and PI3Kgamma one step ahead -- Dual active PI3Kdelta/gamma inhibitors for the treatment of immune-mediated inflammatory diseases -- Oncogenic Mutations of PIK3CA in Human Cancers -- Structural Effects of Oncogenic PI3Kalpha Mutations -- Comparing the roles of the p110alpha and p110beta isoforms of PI3K in signaling and cancer -- Phosphatidylinositol 3-kinase (PI3K): The oncoprotein -- AKT Signaling in Physiology and Disease -- Faithfull modeling of PTEN loss driven diseases in the mouse -- PI3K as a target for therapy in haematological malignancies -- Clinical development of Phosphatidylinositol-3 kinase pathway inhibitors -- New inhibitors of the PI3K-Akt-mTOR pathway: Insights into mTOR signaling from a new generation of Tor kinase domain inhibitors (TORKinibs) -- Small molecule inhibitors of the PI3-kinase family -- Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance -- Subject index |
| Summary |
From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Phosphoinositides -- Physiological effect
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Protein kinases.
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Cellular signal transduction.
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Protein Kinase Inhibitors -- therapeutic use
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Protein Kinases -- physiology
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Signal Transduction
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Protein Kinases
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MEDICAL -- Biochemistry.
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Cellular signal transduction
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Phosphoinositides -- Physiological effect
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Protein kinases
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| Form |
Electronic book
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| Author |
Rommel, Christian
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Vanhaesebroeck, Bart
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Vogt, Peter K
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| ISBN |
9783642136634 |
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364213663X |
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9783642136627 |
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3642136621 |
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