Cough: Setting the Scene -- Cough Sensors. I. Physiological and Pharmacological Properties of the Afferent Nerves Regulating Cough -- Cough Sensors. II. Transient Receptor Potential Membrane Receptors on Cough Sensors -- Cough Sensors. III. Opioid and Cannabinoid Receptors on Vagal Sensory Nerves -- Cough Sensors. IV. Nicotinic Membrane Receptors on Cough Sensors -- Cough Sensors. V. Pharmacological Modulation of Cough Sensors -- Peripheral Mechanisms I: Plasticity of Peripheral Pathways -- Peripheral Mechanisms II: The Pharmacology of Peripherally Active Antitussive Drugs -- Central Mechanisms I: Plasticity of Central Pathways -- Central Mechanisms II: Pharmacology of Brainstem Pathways -- Central Mechanisms III: Neuronal Mechanisms of Action of Centrally Acting Antitussives Using Electrophysiological and Neurochemical Study Approaches -- Central Mechanisms IV: Conscious Control of Cough and the Placebo Effect -- Clinical Cough I: The Urge-To-Cough: A Respiratory Sensation -- Clinical Cough II: Therapeutic Treatments and Management of Chronic Cough -- Clinical Cough III: Measuring the Cough Response in the Laboratory -- Clinical Cough IV:What is the Minimal Important Difference for the Leicester Cough Questionnaire? -- Clinical Cough V: Complementary and Alternative Medicine: Therapy of Cough -- Clinical Cough VI: The Need for New Therapies for Cough: Disease-Specific and Symptom-Related Antitussives
Summary
This text shows that basic studies are pointing to many potentially valuable approaches to the treatment of cough, based on understanding the basic peripheral receptor mechanisms, the brainstem pathways in the control of cough, and the sensitization processes that may apply in disease