Title Dopamine and glutamate in psychiatric disorders / edited by Werner J. Schmidt and Maarten E.A. Reith

Published Totowa, N.J. : Humana Press, ©2005

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Description 1 online resource (xiv, 600 pages) : illustrations Contents Part I. Dopamine. Dopamine Receptors / Kim A. Neve ; Dopamine Receptor Alternative Splicing / Neil M. Richtand, Laurel M. Pritchard, and Lique M. Coolen -- Part II. Glutamate. Glutamatergic Pathways: Their Relevance for Psychiatric Diseases / Yoland Smith ; Glutamate Receptors: Ionotropic / Daniel T. Monaghan, Julia C.A. More, Bihua Feng, and David E. Jane ; Metabotropic Glutamate Receptors / Krystyna Ossowska -- Part III. Schizophrenia. Dopamine and Schizophrenia / Bart A. Ellenbroek ; Glutamate and Schizophrenia and the N-Methyl-D-Aspartate Receptor Hypofunction Hypothesis / Stefan Bleich and Johannes Kornhuber ; Role of Glycine in Schizophrenia / Beate D. Kretschmer -- Part IV. Depression. Dopamine and Depression / Phil Skolnick ; Glutamate and Depression / Joaquín Del Río and Diana Frechilla -- Part V. Stress and Aggression. Dopamine, Glutamate, and Aggression / Klaus A. Miczek and Eric W. Fish -- Part VI. Anxiety. Glutamatergic Systems and Anxiety / David N. Stephens -- Part VII. Attention Deficit Hyperactivity Disorder. Dopamine and Glutamate in Attention Deficit Hyperactivity Disorder / James M. Swanson, Nora D. Volkow, Jeffrey Newcorn, B.J. Casey, Robert Moyzis, David K. Grandy, and Michael I. Posner -- Part VIII. Addiction. Dopamine-Glutamate Interactions in Reward-Related Incentive Learning / Richard J. Beninger and Todor V. Gerdjikov ; Sensitization and Relapse: Dopamine-Glutamate Interactions / David A. Baker and Peter W. Kalivas ; Glutamatergic Neurotransmission in Sensitization / Thomas M. Tzschentke ; Glutamatergic Mechanisms of Drug Relapse: Withdrawal and Conditioning Factors / Anton Y. Bespalov and Robert L. Balster -- Part IX. Neurodegeneration. Dopamine and Neurodegeneration / Gabriele Gille and Peter Riederer ; Glutamate and Neurodegeneration / Antonello Novelli, Marcos Pérez-Basterrechea, and Maria Teresa Fernández-Sánchez -- Part X. Parkinson's Disease. Presymptomatic and Symptomatic Stages of Intracerebral Inclusion Body Pathology in Idiopathic Parkinson's Disease / Heiko Braak and Kelly Del Tredici ; Dopamine and Glutamate in Parkinson's Disease: Biochemistry, Clinical Aspects, and Treatment / Heinz Reichmann, Bernd Janetzky, and Peter Riederer ; Dopamine and Glutamate in Motor and Cognitive Symptoms of Parkinson's Disease / Werner J. Schmidt -- Part XI. Huntington's Disease. Dopamine and Glutamate in Huntington's Disease / Carlos Cepeda, Marjorie A. Ariano, and Michael S. Levine -- Part XII. Dementias. Dopaminergic and Glutamatergic Systems in Alzheimer's Disease / Paul T. Francis Summary Continous rigorous research in basic neurosciences and in clinical studies has enormously increased our knowledge of the neurobiological basis of mental functions and of the neuronal dysfunctions underlying such diseases as schizophrenia, depression, attention deficit disorder, and Parkinson's disease. A transmitter system does not work in isolation, it interacts with other transmitters and the balance between several transmitter determines the outcome, either physiological or pathological. Such a critical balance exists between dopamine and glutamate, which in many brain areas play functionally opposing roles. In Dopamine and Glutamate in Psychiatric Disorders, a panel of neurochemists, pharmacologists, experimental psychologists, and clinicians summarizes our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and from that develops novel therapeutic strategies and possibilities for the future. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, on the origin, progression, and cognitive aspects of Parkinson's disease. Additional chapters offer illuminating insights into a variety of psychiatric diseases, including attention deficit hyperactivity disorder, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques. The authors also offer a critical selection and evaluation of relevant literature and a description of future directions for new therapy development. Path-breaking and insightful, Dopamine and Glutamate in Psychiatric Disorders offers behavioral pharmacologists, neurobiologists, and clinicians an enlightening review of the neurobiological basis and treatment strategies of today's most important psychiatric and neurological diseases Bibliography Includes bibliographical references and index Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL Print version record digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL Subject Neuropsychiatry. Dopamine -- Pathophysiology Glutamic acid -- Pathophysiology Neurotransmitter receptors. Dopamine. Glutamic acid. Mental Disorders -- drug therapy Mental Disorders -- etiology Antidepressive Agents -- pharmacology Antipsychotic Agents -- pharmacology Dopamine Glutamic Acid Nervous System Diseases -- drug therapy Nervous System Diseases -- etiology Receptors, Dopamine Receptors, Glutamate Receptors, Neurotransmitter HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain) MEDICAL -- Neurology. Glutamic acid Dopamine Neuropsychiatry Neurotransmitter receptors Form Electronic book Author Schmidt, Werner J. Reith, Maarten E. A. ISBN 9781592598526 1592598528

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