Snake venoms and envenomation : modern trends and future prospects / editors, Yuri N. Utkin, and Arcadius V. Krivoshein (Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia, and others)
Published
Hauppauge, New York : Nova Science Publisher's, Inc., [2016]
SNAKE VENOMS AND ENVENOMATION MODERN TRENDS AND FUTURE PROSPECTS; SNAKE VENOMS AND ENVENOMATION MODERN TRENDS AND FUTURE PROSPECTS; Library of Congress Cataloging-in-Publication Data; CONTENTS; PREFACE; SECTION ONE: GENERAL ASPECTS; Chapter 1: SNAKES: DIVERSITY, EPIDEMIOLOGY AND ENVENOMATION; ABSTRACT; GENERAL ASPECTS; EPIDEMIOLOGY AND ENVENOMATION; South Asia; Africa; Europe; Americas; Australia; CONCLUSION; REFERENCES; Chapter 2: VENOMS FROM "NON-VENOMOUS" SNAKES: REAR-FANGED SNAKE VENOMS AS SOURCES OF NOVEL COMPOUNDS; ABSTRACT; INTRODUCTION
BIOLOGY OF REAR-FANGED SNAKES: ITS RELEVANCE TO TOXINOLOGISTSDiversity; Gland Structure -- The Duvernoy's Venom Gland; Venom Yields; COMPOSITION OF VENOM FROM REAR-FANGED SNAKES; Analysis of Venoms; Mass Spectrometry, Proteomic Analysis and Transcriptomic Analyses ofRear-Fanged Snake Venoms; Enzymes; PIII Metalloprotease; Matrix Metalloproteinase; Serine Proteinase; Acetylcholinesterase (AChE); Phospholipase A2; Non-Enzymatic Toxins; Cysteine-Rich Secretory Proteins (CRiSPs); Three-Finger Toxins; Other Components; DRUG DEVELOPMENT POTENTIAL; CONCLUSION AND FUTURE DIRECTIONS; REFERENCES
Chapter 3: VENOM PRODUCTION IN THE 21ST CENTURYABSTRACT; INTRODUCTION; LEGAL CONSIDERATIONS; SAFETY; HUSBANDRY; Biology of the Animals; New Specimens; Feeding; Disease Control; Cleaning/Disinfecting; Record Keeping; Breeding; EXTRACTIONS; REFERENCES; SECTION TWO: CLINICAL AND PATHOPHYSIOLOGICAL ASPECTS; Chapter 4: EXTENDING THE USE OF SNAKE VENOMS TO THERAPEUTICS; ABSTRACT; INTRODUCTION; HISTORICAL USE; DRUG QUALITY; DRUG ENGINEERING; ROUTE OF ADMINISTRATION OPTIONS; PRODUCT PROTECTION STRATEGIES; Patent Term Extensions; Orphan Drug Status
New Chemical/Molecular Entities (NCE/NME) Market ExclusivityBiologic Exclusivity; PRECLINICAL ANIMAL STUDIES; REGULATORY STRATEGY; CLINICAL TRIALS; CONCLUSION; REFERENCES; Chapter 5: PATHOPHYSIOLOGICAL SIGNIFICANCE AND THERAPEUTIC IMPLICATIONS OF RUSSELL'S VIPER VENOM PROTEINS AND PEPTIDES AFFECTING BLOOD COAGULATION; ABSTRACT; INTRODUCTION; HEMOSTATICALLY ACTIVE PROTEINS AND PEPTIDES FROM RVV; Procoagulant Proteins Isolated from RVV: Structure-Functional Propertiesand Mechanisms of Action; Factor X Activators; Factor V Activators; Thrombin-Like Enzymes; Prothrombin Activators
Anticoagulant Proteins from RVV: Structure-Functional Properties andMechanisms of ActionAnticoagulant Proteins Possessing Enzymatic Activity; Phospholipase A2 (PLA2) Enzymes; Fibrino(geno)lytic Proteases; Non-Enzymatic Anticoagulant Proteins/Peptides; Kunitz-Type Serine Protease Inhibitors; C-Type Lectin Like Proteins; An Apoptosis-Inducing Anticoagulant Peptide; Pharmacological Properties and Toxicity of Procoagulant and Anticoagulant Proteins/Peptides Purified from RVV; Biomedical Applications of RVV Proteins/Peptides Affecting Hemostasis; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES
Bibliography
Includes bibliographical references and index
Notes
Print version record and CIP data provided by publisher
