| Description |
1 online resource (xxiv, 314 pages) : illustrations |
| Contents |
Book Cover -- Title -- Contents -- List of figures -- List of tables -- Preface -- Introduction -- Organ-selective toxicity -- Cellular transport and selective accumulation of potentially toxic xenobiotics -- Bioactivation of xenobiotics to reactive metabolites -- Xenobiotic-induced oxidative stress: cell injury, signaling, and gene regulation -- Disruption of cellular calcium homeostasis -- Mechanisms of necrotic and apoptotic cell death -- Impairment of cell proliferation and tissue repair -- Covalent binding of reactive metabolites to cellular macromolecules -- Immune mechanisms -- Cytokine-mediated toxicity -- Specific inactivation of enzymes and other proteins -- Nuclear receptor-mediated toxicity -- Interactions of xenobiotics with ion transporters -- Disruption of cellular energy production by xenobiotics -- Outlook: from mechanisms to individual expression of genes -- Review QA -- Index |
| Summary |
Reductionism to cellular and molecular mechanisms is one of the cornerstones of modern toxicology, forming the basis for a better understanding of individual toxic effects, and providing an important tool for human risk assessment. Mechanistic Toxicology is a timely textbook that provides an introduction to this important, but often neglected, area within the toxicological sciences. This book gives new insights into the processes and mechanisms underlying the toxicity of chemicals and explains how foreign compounds (drugs, environmental pollutants, industrial chemicals) exert their potentially damaging effects on cells and tissues. Features include:*an extensive number of illustrations, tables and photographs*summaries of the main learning points*question and answer reviews at the end of each chapterMechanistic Toxicology incorporates recent advances in molecular biology and develops concepts for the reader in a logical way. It also illustrates, using many examples and complementary background information, how a better understanding of these mechanistic pathways helps in estimating potential risk to human health. Ideal for use in undergraduate and graduate classes of pharma-toxicology and environmental toxicology, Mechanistic Toxicology is also a valuable reference for any other readers interested in this subject |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Molecular toxicology.
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Cellular signal transduction.
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Toxicology -- methods
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Molecular Biology
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Signal Transduction
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Xenobiotics -- pharmacokinetics
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Xenobiotics -- toxicity
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MEDICAL -- Toxicology.
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Cellular signal transduction
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Molecular toxicology
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| Form |
Electronic book
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| ISBN |
0203361768 |
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9780203361764 |
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