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Title Peroxisomes : biology and importance in toxicology and medicine / edited by Gordon Gibson and Brian Lake
Published London ; Washington, DC : Taylor & Francis, 1993


Description 1 online resource (xiv, 734 pages) : illustrations (some color)
Contents Peroxisome biogenesis -- Metabolic role of mammalian peroxisomes -- Peroxisomal disorders -- Molecular mechanism of peroxisome proliferator action -- Peroxisome proliferators as cytochrome P450 inducers -- Peroxisome proliferation: lipid metabolism and receptors -- Molecular mechanisms involved in induction of peroxisomal [beta]-oxidation enzymes by hypolipidaemic agents -- Molecular basis of gene regulation by peroxisome proliferators -- Molecular evolution of the urate oxidase encoding gene and its functional significance -- Possible role of CoASH esters on xenobiotic-induced peroxisomal proliferation and non-genotoxic carcinogenesis -- Modulation of peroxisomal biogenesis and lipid metabolising enzymes by dietary factors
(cont) Proliferation of peroxisomes and mitochondria and modulation of lipid metabolizing enzymes by hypolipidaemic, non-[beta]-oxidizable fatty acids (3-thia fatty acids) -- Cultured hepatocytes: a useful in vitro system to investigate effects induced by peroxisome proliferators and their species specificity -- Structure-activity relationships for chemically induced peroxisome proliferation in mammalian liver -- Tetrazole substituted acetophenone peroxisome proliferators: structure-activity relationships and effects on hepatic lipid metabolism -- Structural requirements for peroxisome proliferation by phenoxyacetic and fatty acid analogues in primary cultures of rat hepatocytes -- Ultrastructural and biochemical aspects of peroxisome proliferation and biogenesis in different mammalian species -- Toxicological studies in primates with three fibrates
Structure-, enantiomer- and species-specific effects of fibrate analogues on peroxisome proliferation and increased activity of mitochondrial [alpha]-glycerophosphate dehydrogenase -- Metabolism of di-(2-ethylhexyl)phthalate (DEHP) and di-(2-ethylhexyl)adipate (DEHA) and their relationship to peroxisome proliferation in different species -- Extrahepatic peroxisome proliferation and the extrahepatic effects of peroxisome proliferators -- Biological aspects of peroxisome proliferator-induced liver tumours in the rat -- Genotoxicity studies of peroxisome proliferators -- Production of 8-hydroxydeoxyguanosine in rodent liver by the administration of peroxisome proliferators -- Role of oxidative stress and enhanced cell replication in the hepatocarcinogenicity of peroxisome proliferators -- Hyperplastic responses to peroxisome proliferators
(cont) Hepatic changes associated with peroxisome proliferation -- Peroxisome proliferators as initiators and promoters of rodent hepatocarcinogensis -- Are peroxisome proliferators tumour promoters in rat liver? -- Risk assessment of chemicals inducing peroxisome proliferation
Summary There is currently interest in the effect of peroxisome proliferation, and in proliferators and their modes of action. Peroxisomes (or "microbodies") are single membrane-limited cytoplasmic organelles present in the cells of animals, plants, fungi and protozoa.; This book describes the basic structure and functions of these organelles which are responsible for many cellular functions including an active auxilliary fatty acid B-oxidation system. During treatment with severally clinically used drugs and environmental contaminants, the synthesis of peroxisomes is greatly increased, this proliferation having a number of toxicological consequences particularly in relation to liver cancer
Analysis Mammals Cells Biochemistry
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Peroxisomes.
42.15 cytology, cell biology and cell physiology.
SCIENCE -- Life Sciences -- Cell Biology.
Form Electronic book
Author Gibson, G. Gordon
Lake, Brian, 1948-
ISBN 0203481518