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Book Cover
Author Youssef, Jihan A., 1959-

Title Peroxisome proliferator-activated receptors : discovery and recent advances / Jihan A. Youssef, Mostafa Z. Badr
Published New York : Humana Press, ©2013


Description 1 online resource
Contents Introduction -- History of PPAR Discovery -- Peroxisome Proliferator-Activated Receptors -- PPAR Ligands -- Tissue Distribution and Versatile Functions of PPARs -- PPARs and Drug Metabolism -- Molecular Aspects of PPAR Actions -- Animal Models in PPAR Research -- Safety of PPAR Agonists -- The Future of PPAR Research
Summary All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described. As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions
Analysis Life sciences
Cell receptors
Bibliography Includes bibliographical references and index
Notes English
In Springer eBooks
Subject Peroxisomes -- Receptors
Peroxisome Proliferator-Activated Receptors
SCIENCE -- Life Sciences -- Cell Biology.
Cell receptors
Form Electronic book
Author Badr, Mostafa Z., 1950-
ISBN 9781627034203