| Description |
1 online resource (52 pages) : illustrations (some color) |
| Series |
SpringerBriefs in biochemistry and molecular biology, 2211-9353 |
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SpringerBriefs in biochemistry and molecular biology.
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| Contents |
Preface; Contents; 1 Gamma-Glutamyl Transpeptidases: Structure and Function; Abstract; 1 ... Introduction; 2 ... Occurrence, Genes, and Gene Expression; 2.1 Hepatic Expression of gamma -GT; 2.2 gamma -GT Gene Structure; 2.3 Induction of Hepatic gamma -GT; 2.4 gamma -GT-Related Gene Products; 3 ... Structure and Function of gamma -GTs; 4 ... Autoprocessing and Reaction Mechanism of gamma -GTs; 4.1 Autoprocessing; 4.2 Reaction Mechanism; 4.3 gamma -Glutamyl Binding Site; 4.4 Acceptor Binding Site; 4.5 Transpeptidation Versus Hydrolysis; 4.6 Enzymatic Assays; 4.7 Biochemical Properties of gamma -GTs |
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4.8 Quest for Inhibitors4.9 Inhibitor Mechanisms; 4.10 Conformational Stability of gamma -GTs; 4.11 Search for Thermostable gamma -GTs; 5 ... gamma -GT in Bioclinical; 5.1 Pathways of gamma -GT Induction; 5.2 gamma -GT and Cancer; 5.3 gamma -GT and Cisplatin Resistance; 5.4 gamma -GT and Tumor Progression; 5.5 gamma -GT as a Target for Anticancer Treatments; 5.6 gamma -GT Complexes: Novel Biomarkers for Cancer and Other Pathologies; 6 ... gamma -GTs: Biotechnological and Biomedical Applications; 6.1 gamma -GTs in the Production of SCV-07 and of Glutamyl Phenyl Hydrazine Analogs |
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6.2 gamma -GTs as Cephalosporin Acylases6.3 gamma -GTs as Glutaminases; 6.4 gamma -GTs in the Production of Theanine; 6.5 gamma -GT to Release Drugs; 7 ... Conclusions; References |
| Summary |
Gamma-Glutamyl Transpeptidases (y-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the y-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released y-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). y-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.y-GT is upregulated during inflammation and in several human tumors, and it is involved in |
| Analysis |
Life sciences |
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Human physiology |
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Biochemical engineering |
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Enzymes |
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Enzymology |
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levenswetenschappen |
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fysiologie |
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physiology |
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engineering |
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biochemie |
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biochemistry |
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enzymologie |
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Biology (General) |
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Biologie (algemeen) |
| Bibliography |
Includes bibliographical references |
| Notes |
English |
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Online resource; title from title details screen (SpringerLink, viewed July 22, 2013) |
| In |
Springer eBooks |
| Subject |
Peptidase.
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Transpeptidation.
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Enzymes.
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gamma-Glutamyltransferase -- physiology
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Transglutaminases -- physiology
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Peptide Hydrolases
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Enzymes
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enzyme.
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SCIENCE -- Life Sciences -- Biochemistry.
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Peptidase
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Transpeptidation
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| Form |
Electronic book
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| Author |
Merlino, Antonello
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| ISBN |
9783034806824 |
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3034806825 |
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3034806817 |
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9783034806817 |
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1299856853 |
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9781299856851 |
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