| Description |
1 online resource (xii, 522 pages) : illustrations |
| Series |
Advances in experimental medicine and biology, 0065-2598 ; v. 477 |
|
Advances in experimental medicine and biology ; v. 477. 0065-2598
|
| Contents |
Membrane Ectopeptidases with Influence on Immune Functions -- Review: The Role of Membrane Peptidases in Immune Functions / Uwe Lendeckel, Thilo Kahne, Dagmar Riemann, Klaus Neubert, Marco Arndt, Dirk Reinhold -- Structure and Function of Aminopeptidase N / Hans Sjostrom, Ove Noren, Jorgen Olsen -- Modulation of WNT-5a Expression by Actinonin: Linkage of APN to the WNT-Pathway? / Uwe Lendeckel, Marco Arndt, Karin Frank, Antje Spiess, Dirk Reinhold, Siegfried Ansorge -- Enzymatic Activity is not a Precondition for the Intracellular Calcium Increase Mediated by mAbs Specific for Aminopeptidase N/CD13 / Alexander Navarrete Santos, Jurgen Langner, Dagmar Riemann -- Transforming Growth Factor-[beta] Increases the Expression of Aminopeptidase N/CD13 mRNA and Protein in Monocytes and Monocytic Cell Lines / Astrid Kehlen, Jurgen Langner, Dagmar Riemann -- Cell-Cell Contact Between Lymphocytes and Fibroblast-like Synoviocytes Induces Lymphocytic Expression of Aminopeptidase N/CD13 and Results in Lymphocytic Activation / Dagmar Riemann, Jana Rontsch, Bettina Hause, Jurgen Langner, Astrid Kehlen -- Natural Substrates of Dipeptidyl Peptidase IV / Ingrid De Meester, Christine Durinx, Gunther Bal, Paul Proost, Sofie Struyf, Filip Goossens, Koen Augustyns, Simon Scharpe -- Relating Structure to Function in the Beta-Propeller Domain of Dipeptidyl Peptidase IV: Point Mutations that Influence Adenosine Deaminase Binding, Antibody Binding and Enzyme Activity / Mark D. Gorrell, Catherine A. Abbott, Thilo Kahne, Miriam T. Levy, W. Bret Church, Geoffrey W. McCaughan |
| Summary |
Of the many special roles played by proteolytic enzymes in immune reactions, this book addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a unique feature of this multifaceted work, which combines biochemical, immunological and clinical research reports with literary reviews of the field |
| Notes |
Proceedings of an International Conference on Cellular Peptidases in Immune Functions and Diseases (II), held September 12-14, 1999, in Magdeburg, Germany |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Peptidase -- Immunology -- Congresses
|
|
Peptidase -- Pathophysiology -- Congresses
|
|
Endopeptidases -- Immunology -- Congresses
|
|
Endopeptidases -- Pathophysiology -- Congresses
|
|
Peptide Hydrolases -- immunology
|
|
Peptide Hydrolases -- physiology
|
|
MEDICAL -- Immunology.
|
|
Peptidase -- Immunology
|
| Genre/Form |
proceedings (reports)
|
|
Conference papers and proceedings
|
|
Conference papers and proceedings.
|
|
Actes de congrès.
|
| Form |
Electronic book
|
| Author |
Langner, Jürgen
|
|
Ansorge, Siegfried
|
|
International Conference on Cellular Peptidases in Immune Functions and Diseases (2nd : 1999 : Magdeburg, Germany)
|
| ISBN |
0306468263 |
|
9780306468261 |
|
