Ch. 1. Why ethical review? The moral context of clinical research -- Ch. 2. The main job: protecting the interests of the research subject -- Ch. 3. Research design and methodology: built-in risks -- Ch. 4. Experimental clinical practice -- Ch. 5. Balancing risks and benefits -- Ch. 6. What is this thing called consent? -- Ch. 7. The value of a committee - expertise, representation and accountability -- Ch. 8. Good ethical review in practice -- Ch. 9. The pro-forma application form and its requirements -- Ch. 10. Ethical review and the law -- Ch. 11. Why local? The importance of variable circumstances -- Ch. 12. The special challenge of multi-location research -- Ch. 13. The future of ethical review