A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Partially ordered sets -- Congresses : Recent developments in algebraic and combinatorial aspects of representation theory : International Congress of Mathematicians Satellite Conference on Algebraic and Combinatorial Approaches to Representation Theory, August 12-16, 2010, National Institute of Advanced Studies, Bangalore, India : follow-up conference May 18-20, 2012, University of California, Riverside, CA / Vyjayanthi Chari, Jacob Greenstein, Kailash C. Misra, K.N. Raghavan, Sankaran Viswanath, editors
Participación ciudadana -- Brasil : Widening democracy : citizens and participatory schemes in Brazil and Chile / edited by Patricio Silva and Herwig Cleuren
2009
1
Participación ciudadana -- Chile : Widening democracy : citizens and participatory schemes in Brazil and Chile / edited by Patricio Silva and Herwig Cleuren
2009
1
Participación política -- Brasil : Widening democracy : citizens and participatory schemes in Brazil and Chile / edited by Patricio Silva and Herwig Cleuren
2009
1
Participación política -- Chile : Widening democracy : citizens and participatory schemes in Brazil and Chile / edited by Patricio Silva and Herwig Cleuren
Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from http://clinicalcenter.nih.gov/recruit/volunteers.html, accessed 2/14/2013)
Participant observation -- Michigan -- Detroit. : A practical guide to biological primary data collection in an impoverished urban setting : illuminating structural and social influences on population health inequity / Jay A. Pearson, Arline T. Geronimus
Participant observation -- Solomon Islands. : The ethnographic experiment : A.M. Hocart and W.H.R. Rivers in island Melanesia, 1908 / edited by Edvard Hviding and Cato Berg
Participant observation -- Vietnam, Northern. : Opening up knowledge production through participatory research? : agricultural research for Vietnam's northern uplands / Jakob Rupert Friederichsen
Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from http://clinicalcenter.nih.gov/recruit/volunteers.html, accessed 2/14/2013)
