A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
1
Partialdruck : Oxygen sensing : responses and adaptation to hypoxia / edited by Sukhamay Lahiri, Gregg L. Semenza, Nanduri R. Prabhakar
Partially ordered sets -- Congresses : Recent developments in algebraic and combinatorial aspects of representation theory : International Congress of Mathematicians Satellite Conference on Algebraic and Combinatorial Approaches to Representation Theory, August 12-16, 2010, National Institute of Advanced Studies, Bangalore, India : follow-up conference May 18-20, 2012, University of California, Riverside, CA / Vyjayanthi Chari, Jacob Greenstein, Kailash C. Misra, K.N. Raghavan, Sankaran Viswanath, editors
Participação política -- América latina. : The new politics of inequality in Latin America : rethinking participation and representation / edited by Douglas A. Chalmers [and others]
Participació educativa. : Family-school partnerships during the early school years : advancing science to influence practice / Karen L. Bierman, Susan M. Sheridan, editors
2022
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Participació política. : Youth participation and learning : critical perspectives on citizenship practices in Europe / Zulmir Bečević, Björn Andersson, editors
Participación ciudadana -- Brasil : Widening democracy : citizens and participatory schemes in Brazil and Chile / edited by Patricio Silva and Herwig Cleuren
2009
1
Participación ciudadana -- Chile : Widening democracy : citizens and participatory schemes in Brazil and Chile / edited by Patricio Silva and Herwig Cleuren
2009
1
participación comunitaria. : Health microinsurance schemes : monitoring and evaluation guide / International Labour Office
Participación política -- Brasil : Widening democracy : citizens and participatory schemes in Brazil and Chile / edited by Patricio Silva and Herwig Cleuren
2009
1
Participación política -- Chile : Widening democracy : citizens and participatory schemes in Brazil and Chile / edited by Patricio Silva and Herwig Cleuren
2009
1
Participación política -- Europa : Citizens and democracy in Europe : contexts, changes and political support / Sergio Martini, Mario Quaranta
Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from http://clinicalcenter.nih.gov/recruit/volunteers.html, accessed 2/14/2013)
Participant observation -- Michigan -- Detroit. : A practical guide to biological primary data collection in an impoverished urban setting : illuminating structural and social influences on population health inequity / Jay A. Pearson, Arline T. Geronimus
Participant observation -- Philosophy : Arts-based methods for decolonising participatory research / edited by Tiina Seppälä, Melanie Sarantou and Satu Miettinen
