| Description |
1 online resource |
| Series |
Current topics in behavioral neurosciences, 1866-3370 ; v. 45 |
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Current topics in behavioral neurosciences ; 45.
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| Contents |
Intro -- Preface -- Contents -- A Review of the Cholinergic System and Therapeutic Approaches to Treat Brain Disorders -- 1 Cholinergic System Overview -- 1.1 Acetylcholine -- 1.2 Muscarinic ACh Receptors (mAChRs) -- 1.3 Nicotinic ACh Receptors (nAChRs) -- 2 Localization of AChRs in the Central Nervous System -- 2.1 mAChRs -- 2.2 nAChRs -- 3 nAChR Neuronal Expression and Neurotransmission -- 3.1 Ionic Selectivity and Ca2+ Permeability -- 3.2 Voltage Dependence -- 4 Synaptic Plasticity -- 5 Intracellular Signaling -- 5.1 mAChRs -- 5.2 nAChRs -- 6 Receptor Desensitization -- 6.1 mAChRs |
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6.2 nAChRs -- 7 Areas of Continued Investigation -- 8 Cholinergic Receptors as Therapeutic Targets -- 8.1 mAChRs -- 8.2 nAChRs -- References -- Acetylcholine and Spontaneous Recognition Memory in Rodents and Primates -- 1 A Content-Based Approach to Episodic Memory -- 2 The Role of Acetylcholine in What-Where-Which Occasion Memory -- 3 Differential Roles of Acetylcholine in the Hippocampus and Perirhinal Cortex -- 4 Does the What-Where-Which Task Measure Episodic Memory? -- 5 The Role of Acetylcholine in Encoding and Retrieval -- References |
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Endogenous Acetylcholine and Its Modulation of Cortical Microcircuits to Enhance Cognition -- 1 Introduction -- 2 Anatomy of the Cholinergic System in Prefrontal and Sensory Cortices -- 2.1 Cholinergic Innervation of Cerebral Cortex -- 2.2 Cortical Cholinergic Synapses -- 3 Regulation of Cortical Neurons by Endogenous Acetylcholine -- 4 Behavioral Consequences of Endogenous Acetylcholine Release in Cerebral Cortex -- 5 Conclusions and Directions for Future Research -- References -- Cholinergic Signaling Dynamics and Cognitive Control of Attention -- 1 Introduction |
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2 Cortical ACh and Attentional Performance -- 3 Prefrontal Cholinergic Mechanisms of Signal Detection and Attentional Control -- 3.1 Phasic ACh Release Mediates Cue Detection -- 3.2 Top-Down Control of Attention and Cholinergic Neuromodulation -- 4 Cellular Regulation of Cholinergic Signaling Modes -- 4.1 High-Affinity Choline Transporters (CHTs) -- 4.2 nAChRs -- 4.3 mAChRs -- 5 Sex Differences and the Cholinergic Mediation of Attention -- 5.1 Neurochemical Sex Differences -- 5.2 Behavioral Sex Differences -- 6 Conclusions -- References |
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Involvement of Nicotinic Receptors in Working Memory Function -- 1 Introduction -- 2 Cholinergic Nuclei and Projections -- 3 Cholinergic Regulation of Arousal State -- 4 Acetylcholine in PFC and Attention -- 5 Acetylcholine in Working Memory -- 6 Cholinergic Modulation of Cognitive Control -- 7 Relevance to Disease -- 8 Conclusion -- References -- Nicotinic Receptors Underlying Nicotine Dependence: Evidence from Transgenic Mouse Models -- 1 Introduction -- 2 nAChR Function and Signaling -- 3 nAChRs Mediating Nicotine Reinforcement -- 3.1 Mesolimbic Pathway -- 3.2 Habenulo-Interpeduncular Pathway |
| Summary |
The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments |
| Subject |
Acetylcholine -- Receptors.
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Parasympathomimetic agents.
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Cholinergic mechanisms.
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Receptors, Cholinergic
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Parasympathomimetics
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Neurosciences.
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Medical -- Neuroscience.
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Acetylcholine -- Receptors
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Cholinergic mechanisms
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Parasympathomimetic agents
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Neurociència cognitiva.
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Sistema nerviós.
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Farmacologia.
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| Genre/Form |
Llibres electrònics.
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| Form |
Electronic book
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| Author |
Shoaib, Mohammed, editor.
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|
Wallace, Tanya L., editor.
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| ISBN |
9783030560133 |
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3030560139 |
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