| Description |
1 online resource (viii, 251 pages) : illustrations (some color) |
| Contents |
Intro -- Preface -- Contents -- Part I: Clinically Relevant Science -- Epidemiology of Acute Pancreatitis -- 1 Introduction -- 2 Global Incidence and Temporal Trends -- 3 Demographic and Socioeconomic Factors -- 4 Relevant Discussion by Etiology (Table 1) -- 4.1 Gallstone-Related AP -- 4.2 Alcohol-Related AP -- 4.3 Hypertriglyceridemia (HTG)-Related AP -- 4.4 Medication-Induced AP -- 4.5 Post-ERCP Pancreatitis (PEP) -- 5 Other Causes and Risk Factors for AP -- 5.1 Pancreas Divisum -- 5.2 Neoplasia -- 5.3 Celiac Disease and Other Autoimmune Diseases |
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5.4 Autoimmune Pancreatitis (AIP) -- 5.5 Genetic Factors -- 5.6 Infectious Causes -- 5.7 Hypercalcemia -- 5.8 Tobacco Use -- 5.9 Diabetes -- 5.10 End-Stage Renal Disease (ESRD) and Renal Replacement Therapy -- 5.10.1 Idiopathic AP -- 5.10.2 Geographic Differences in AP Phenotype -- 5.10.3 Recurrent Acute Pancreatitis -- 5.10.4 Chronic Pancreatitis -- 6 Long-Term Sequalae of AP -- 6.1 Diabetes -- 6.2 Exocrine Pancreatic Insufficiency (EPI) -- 6.3 Quality of Life (QOL) and Disability -- 7 Holistic Prevention of Pancreatitis -- References -- Genetic Factors in Acute Pancreatitis |
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1 Introduction -- 2 Acute, Recurrent Acute, and Chronic Pancreatitis -- 3 Conceptual Framework -- 4 Genetic Factors Related to the Risk and Etiology of AP -- 4.1 Gallstones -- 4.2 Alcohol -- 4.3 Smoking -- 4.4 Hypertriglyceridemia -- 4.5 Drugs -- 5 Genetic Factors Related to the Severity and Complications of Acute Pancreatitis -- 6 The Timing and Emerging Role of Genetic Testing -- 7 Genetic Factors Related to Preventing Recurrent AP -- 7.1 The Standard Approach to Management of AP without Genetic Information (Fig. 1a) -- 7.2 The Management of AP with Genetic Information (Fig. 1b) |
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8 Summary and Conclusions -- References -- Acinar Cell Events Initiating Acute Pancreatitis -- 1 Preclinical Animal Models of Pancreatitis -- 2 Early Pathologic Events Leading to Pancreatitis -- 3 Trypsinogen Activation -- 4 Cell Death -- 4.1 Types of Eukaryotic Cell Death -- 4.2 Acinar Cell Death in Pancreatitis -- 5 Acinar Cell Events Initiating the Inflammatory Response -- 5.1 Mechanisms Triggering Inflammation -- 5.2 The Inflammatory Response of Pancreatitis -- 6 Acinar Cell Organellar Dysfunctions Initiate and Drive Pancreatitis |
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7 ER Dysfunction and Aberrant Ca2+ Signaling in Pancreatitis -- 7.1 Role of Endoplasmic Reticulum in Protein Folding -- 7.2 Role of Endoplasmic Reticulum in Ca2+ Transport -- 7.3 ER Stress in Pancreatitis -- 7.4 Dysregulation of Ca2+ Signaling in Pancreatitis -- 8 Mitochondrial Dysfunction in Pancreatitis -- 8.1 Mitochondria-Mediated Mechanisms of Cell Death -- 8.2 Mitochondrial Dysfunction Mediates Acinar Cell Death in Pancreatitis -- 8.3 MPTP Inactivation Markedly Improves Experimental Pancreatitis -- 9 Lysosomal/Autophagic Dysfunctions and Their Role in Pancreatitis |
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9.1 The Lysosome |
| Summary |
This book is an accessible, evidence-based, succinct and practical reference for those providing hands-on care to patients with acute pancreatitis. It represents the most updated results of clinical science and offers the frameworks that underpin the disease and its management. The first part of the book presents the latest clinical science and illustrates a clear indication of what is known, and what are the gaps in our understanding of the disease. The second part provides practical clinical management guidelines. The chapters are designed to bring recommendations, practical points to facilitate navigation, easy access of knowledge, and highlights key decision points and options. Acute Pancreatitis - A Practical Guide for Clinicians is relevant to not only clinicians involved in patient care but medical, nursing and dietitian students, surgical and gastroenterology researchers, companies and agencies. The book comprehensively covers acute pancreatitis, associating it with local pancreatic complications, systemic inflammation and organ failures, also providing management algorithms. This practical reference book is an introduction to disease management, indicating why topics addressed in each chapter are essential, providing valuable guidance for day-to-day treatment by professionals globally |
| Bibliography |
Includes bibliographical references |
| Notes |
Description based on online resource; title from digital title page (viewed on September 20, 2024) |
| Subject |
Pancreatitis.
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Pancreatitis
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| Form |
Electronic book
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| Author |
Windsor, John Albert, editor
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Barreto, Savio George, editor.
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Phillips, Anthony Ronald John, editor
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| ISBN |
9789819731329 |
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9819731321 |
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