Drug Evaluations in Pancreatic Cancer Culture Systems; Abstract; 1.1 Introduction; 1.2 Types of Cells and Cell Lines; 1.3 Types of Culturing Systems; 1.4 Applications for Pharmacotherapeutic Evaluations; 1.5 In Vitro Analyses; 1.6 Concluding Remarks; References; Mouse Xenograft Models for Drug Discovery in Pancreatic Cancer; 2.1 Introduction; 2.2 Classical Drug Development Program at the NCI; 2.3 New Animal Models; 2.4 Interpreting Results: Variables and Endpoints; 2.5 Future Approaches in Drug Discovery: Biomarkers and Personalized Therapies; 2.6 Concluding Remarks
Summary
Over the years, tremendous advances have been made in the field of cancer drug discovery, particularly, in the area of molecular and genetic models and technologies. This book describes the development in the application of these models and technologies in pancreatic cancer