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Book Cover
Author Nagaraju, Ganji Purnachandra, author.

Title Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy / Ganji Purnachandra Nagaraju
Edition First edition
Published London : Academic Press, [2019]


Description 1 online resource
Series Cancer sensitizing agents for chemotherapy ; volume 5
Cancer sensitizing agents for chemotherapy ; v. 5.
Contents Front Cover; Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy; Copyright; Dedication; Contents; Contributors; About the Editor; About the Series Editor; Aims and Scope for Series ""Cancer Sensitizing Agents for Chemotherapy; Preface; Chapter 1: Overview of Pancreatic Cancer Biology; Introduction; Pathogenesis and Molecular Biology; Three Biological Stages of Cancer Development; Initiation; Clonal Expansion; Oncogenesis; KRAS; Raf/Mitogen-Activated Protein Kinase (MAPK) Cascade; Phosphoinositide 3-Kinase/ATK Cascade; Nuclear Factor Kappa B Signaling Cascade
Tumor Suppressor GenesCDKN2A; TP53; SMAD4; Introduction to Local and Distant Microenvironments; Familial Pancreatic Cancers; Conclusions; References; Further Reading; Chapter 2: Chemoresistance in Pancreatic Cancer: Emphasis on Age and Gender; Introduction; Pancreatic Cancer Incidences and Prognosis: Association of Age and Gender; Chemoresistance: Association With Age and Gender; Mechanisms Associated With Chemoresistance; Factors Modulated in Various Age Groups; Conclusion; Acknowledgments; References; Chapter 3: EMT Contributes to Chemoresistance in Pancreatic Cancer; Introduction
Gemcitabine SensitivityGemcitabine and Chemoresistance; Role of Gemcitabine in Targeting Signaling Pathways; Conclusion; Acknowledgment; References; Chapter 5: Pancreatic Cancer and Possible Therapeutic Options; Introduction; Reasons Behind the Above Statistics?; Brief Outline of Treatment; Tumor-Node-Metastasis Staging and Clinical Classification; Modalities for Evaluating TNM Staging; Clinical Classification; Treatment Options for Pancreatic Adenocarcinoma; Localized Surgically Resectable Stage I and II Disease; Adjuvant Therapy; Gemcitabine and 5-Fluorouracil; Gemcitabine and S-1
Gemcitabine and CapecitabineAdjuvant Chemoradiation; Gemcitabine Plus Nab-Paclitaxel; Neoadjuvant Therapy; Adjuvant Therapy in Borderline Removable Pancreatic Carcinoma; Evidence Supporting Neoadjuvant Therapy; FOLFIRINOX as Neoadjuvant Therapy; NAC-GSL (Neoadjuvant Chemotherapy-Gemcitabine, S-1, LV); Metastatic Pancreatic Cancer: Treatment Options; Early Period; First-Line Therapies; FOLFIRINOX; PRODIGE-4/ACCORD-11 Trial; Outcomes of PRODIGE-4/ACCORD-11 Trial; Precautionary and Toxicity Reducing Strategies; Gemcitabine Plus Nab-Paclitaxel; The MPACT Trial
Bibliography Includes bibliographical references and index
Notes Online resource; title from PDF title page (EBSCO, viewed March 4, 2019)
Subject Pancreas -- Cancer
Drug resistance in cancer cells.
Drug Resistance, Neoplasm
Pancreatic Neoplasms -- drug therapy
Drug Therapy
Pancreatic Neoplasms
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Drug resistance in cancer cells.
Pancreas -- Cancer.
Form Electronic book
ISBN 9780128176627