| Description |
1 online resource (xi, 176 pages) : illustrations (some color) |
| Series |
Cell biology research progress |
|
Cell biology research progress.
|
| Contents |
BETA CELLS: FUNCTIONS, PATHOLOGY AND RESEARCH ; BETA CELLS: FUNCTIONS, PATHOLOGY AND RESEARCH ; Contents ; Preface ; Stress and Pancreatic Ý Cell Function: Role of Glucocortoids, Exercise and Glucolipotoxicity; Abstract ; Introduction Ý Cell Adaptation Ý Cell Mass in Obesity ; Life Cycle of the Ý Cell ; Glucocorticoids and Ý Cell Function ; Direct Effects of Glucocorticoids on Ý Cells ; Indirect Effects of Glucocorticoids on Ý Cell Function ; Role of GRs on Ý Cell Survival and Replication ; Intermittent Stress and Ý Cell Function ; Exercise Intervention on Ý Cell Function |
|
Exercise Causes Pancreatic Regeneration in Partial Pancreatectomy Models Disposition Index on Ý Cell Function ; Age and Exercise on Ý Cell Function; Glucolipotoxicity on Ý Cell Function ; Glucotoxicity; Lipotoxicity ; Short Term Effects of FFAs ; Long Term Effects of FFAs ; FFAs and ER Stress ; Conclusion ; References ; The Synergistic Effect of Ý Cell Replacement and Immunotherapy on the Treatment of Type 1 Diabetes ; Abstract ; Introduction Ý-Cell Replacement ; Patient-Specific ß-Cells ; 1. Autologous adult stem cell-derived ß-cells ; 2. Induced pluripotent stem cells |
|
3. Transdifferentiation-induced Ý-like cells Embryonic Stem Cell-Derived ß-Cells ; Islet Transplantation; Pancreas Transplantation ; Immunotherapy ; Immunopathology of T1D ; Treg-Based Immunotherapy ; 1. Evidence of Treg function in the control of T1D ; 2. Mechanisms of Treg function in T1D ; 3. Therapeutic potential of Tregs on T1D ; Antigen/ Antibody-Based Immunotherapy ; The Potential Synergistic Role of Ý-Cell Replacement and Immunotherapy ; 1. Bi-Directional Actions of Cell-Based Therapy ; 2. Multiple Functions of Immunotherapy ; 3. Temporal and Spatial Actions of Immunotherapy |
|
VII. Expression of Results and Statistical Analyses 1. Expression of the results ; 2. Statistical analyses ; Results ; I. Effect of Rimonabant Administration (10 Mg/Kg/D) on Body Weight of ZDF Rats; II. Rimonabant Administration (10 Mg/Kg/D) Prevents the Elevation of Blood Glucose Levels of ZDF Rats ; III. Rimonabant Administration (10 Mg/Kg/D) Reduces the Decline of Insulinemia of ZDF Rats ; IV. Rimonabant Administration (10 Mg/Kg/D) Reduces Cell Dysfunction in ZDF Rats; 1. Insulin secretion during static incubation of islets isolated from ZDF rats treated for 2 weeks |
| Summary |
And Conclusion Acknowledgments ; References; Antagonizing the Endocannabinoid Pathway Prevents the Development of Diabetes and Ý Cell Dysfunction in Zucker Diabetic Fatty Rats ; Abstract ; Methods ; Results ; Introduction ; Materials and Methods ; I. Drugs and Reagents ; II. Animals ; III. Treatment and Follow-up ; IV. Islet Isolation ; V. Glucose-Stimulated Insulin Secretion (GSIS) Assessment by Static Incubation of Isolated ZDF Rat Islets; VI. Glucose-Stimulated Insulin Secretion (GSIS) Assessment by Perifusion of Isolated ZDF Rat Islets |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Pancreatic beta cells.
|
|
Diabetes.
|
|
Islets of Langerhans
|
|
MEDICAL -- Nutrition.
|
|
Diabetes
|
|
Pancreatic beta cells
|
| Form |
Electronic book
|
| Author |
Gallagher, Sarah E
|
| ISBN |
9781617613722 |
|
161761372X |
|
