Part I. Plant. Botanical Aspects -- Part II. History. Prehistory ; Ancient History ; Postclassical History ; Modern History ; Contemporary History -- Part III. Trade. Business of Opium -- Part IV. Alkaloids. Opiates ; Opioids -- Part V. Molecular Basics. Receptors ; Effectors -- Part VI. Benefits and Harms. Metabolism ; Analgesia ; Adverse effects -- Part VII. Therapeutic utility. Uses and issues ; Advances and prospects