Section I : Fundamental concepts in methadone maintenance treatment -- Fundamental clinical concepts in addiction medicine -- Opioid dependence -- Effectivenss of methadone maintenance treatment -- Pharmacology of methadone -- Section II : Framework for methadone maintenance treatment -- Clinical diagnosis for MMT -- Abstinence-based interventions for opioid withdrawl -- Section III : Methadone prescribing protocols and guidelines -- Methadone dosing guidelines -- Urine drug screening in MMT -- Take-home doses -- Termination of MMT -- Section IV : Clinical drug use in methadone patients -- Methadone and pain management -- MMT and concurrent psychiatric illness -- MMT and concurrent medical disorders -- Pregnancy and opioid use -- MMT and special-needs populations -- Methadone and driving