This study identified the protein PARL (Presenilin-associated rhomboid like) as a potential mediator of the mitochondrial abnormalities that are observed in diabetic skeletal muscle. This was demonstrated by analysing PARL expression in an animal model of type 2 diabetes and by investigating the biological effects of genetic variation in the human PARL gene
Notes
Submitted to the School of Medicine of the Faculty of Health, Medicine, Nursing and Behavioural Sciences, Deakin University
Degree conferred 2010
Thesis (Ph.D.)--Deakin University, Victoria, 2009
Bibliography
Includes bibliographical references (leaves 223-256)
