| Description |
1 online resource (vii, 130 pages) : illustrations |
| Series |
Contributions to nephrology, 0302-5144 ; vol. 128 |
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Contributions to nephrology ; vol. 128.
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| Contents |
Germline and somatic mutations in von Hippel-Lindau disease gene and its significance in the development of kidney cancer -- Hereditary papillary renal carcinoma : pathology and pathogenesis -- Renal cell carcinomas in patients on long-term hemodialysis -- TSC1 and TSC2 gene mutations in human kidney tumors -- Classification of renal cell cancer based on (cyto)genetic analysis -- Wilms' tumor and the WT1 gene -- Gene-modified immunotherapy for renal cell carcinoma -- Wilm's tumor (nephroblastoma) -- Pathogenesis of renal cell adenomas and carcinomas in animal models |
| Summary |
Cancer is above all a heritable disorder of somatic cells and gene expression, but environment is also involved in its origin. Hereditary kidney cancer should prove valuable to understand the mechanisms of disease and to the development of therapeutic measures. Recently, scientists have succeeded in cloning and identifying the genes responsible for the following familial kidney cancers: von Hippel-Lindau disease, papillary renal cell carcinoma, tuberous sclerosis and Wilms tumor (all autosomal dominant). This book brings together some of the most recent advances made with respect to kidney cancers: Leading investigators present recent results on VHL, MET, TSC1 and TSC2 and WT1 genes, among others, as well as on environmentally induced kidney cancers (caused by long-term hemodialysis or induced chemically) and their treatments (surgery and gene therapy), providing an excellent survey of this field. This publication will be of interest to both researchers and clinicians concerned with cancer of the kidney |
| Bibliography |
Includes bibliographical references and indexes |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Current copyright fee: GBP36.40 24\0. Uk |
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English |
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digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL |
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Print version record |
| Subject |
Kidneys -- Cancer.
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Kidney Neoplasms
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Kidneys -- Cancer
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Tumeurs du rein.
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Niertumoren.
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Kanker.
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Rein -- Cancer.
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Nierenkrebs -- Aufsatzsammlung.
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| Form |
Electronic book
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| Author |
Hino, Okio
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| ISBN |
9783318004656 |
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3318004650 |
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