| Description |
1 online resource |
| Series |
Advances in neurobiology ; volume 14 |
|
Advances in neurobiology ; 14.
|
| Contents |
Part I: Clinical and Genetic Considerations of LRRK2 Associated Parkinson's Disease -- Leucine-rich repeat kinase (LRRK2) genetics and Parkinson's disease -- Clinical features of LRRK2 carriers with Parkinson's disease -- Part II: Fundamentals of LRRK2 Biology -- LRRK2 phosphorylation -- Understanding the GTPase activity of LRRK2: regulation, function and neurotoxicity -- LRRK2 and autophagy -- Molecular insights and functional implication of LRRK2 dimerization -- LRRK2 and the immune system -- Regulation of LRRK2 by phosphatases -- Part III: LRRK2 Neurodegeneration, Modeling, and Therapeutic Options -- Animal models of LRRK2-associated Parkinson's disease -- LRRK2 and the?LRRKtosome? at the crossroads of programmed cell death: Clues from RIP kinase relatives -- Interaction of LRRK2 and?-synuclein in Parkinson's disease -- Mechanisms of mutant LRRK2 neurodegeneration -- Small molecule inhibitors of LRRK2 |
| Summary |
This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed April 05, 2017) |
| Subject |
Neurogenetics.
|
|
Chromosomes.
|
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Parkinson's disease -- Genetic aspects
|
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Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
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Chromosomes
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MEDICAL -- Physiology.
|
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
|
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Chromosomes
|
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Neurogenetics
|
| Form |
Electronic book
|
| Author |
Rideout, Hardy J., editor
|
| ISBN |
9783319499697 |
|
3319499696 |
|
