Title Axon growth and guidance / edited by Dominique Bagnard

Published New York : Springer Science + Business Media ; Austin, Tex. : Landes Bioscience, ©2007

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Description 1 online resource (xvi, 169 pages) : illustrations Series Advances in experimental medicine and biology ; v. 621 Advances in experimental medicine and biology ; v. 621. Contents Molecular mechanisms of axonal growth / Céline Bouquet and Fatiha Nothias -- Netrins and their receptors / Simon W. Moore, Marc Tessier-Lavigne and Timothy E. Kennedy -- EPH receptors and ephrin ligands in axon guidance / Michael Reber, Robert Hindges, and Greg Lemke -- Role of semaphorins during axon growth and guidance / Eric Koncina [and others] -- Slits and their receptors / Alain Chédotal -- Neurotrophic factors: are they axon guidance molecules? / Sarah Guthrie -- The role of cell adhesion molecules in axon growth and guidance / Hiroyuki Kamiguchi -- Neurotransmitters and the development of neuronal circuits / Tina Ruediger and Juergen Bolz -- The hedgehog, TGF-b/BMP, and Wnt families of morphogens in axon guidance / Frédéric Charron and Marc Tessier-Lavigne -- The role of cyclic nucleotides in axon guidance / Michael Piper, Francis van Horck and Christine Holt -- Membrane lipid rafts and their role in axon guidance / Carmine Guirland and James Q. Zheng -- The role of glial cells in axon guidance, fasciculation, and targeting / Anabel R. Learte and Alicia Hidalgo Summary The complexarchitectureofneuronal networks togetherwith the extraordinary associated functions make the nervous system a fascinating biological structure. The considerable work performed to explore this cellular machinery is nowadays successfulbecause the mysteryofnervous system developmentisbeing unravelled. As described in their outstanding review published 10 years ago in Science.' Marc Tessier-Lavigne and Corey Goodman-the pioneers of the molecular era of axon guidance-summarized the assembly of nervous system connections as a subtle game of attraction and repulsion of neuronal growth cones. The cellular ballet ensuring the formation of billions of synapses, which ultimately gives rise to the highest cognitive functions, is primarily orchestrated by a step-by-step mechanism of growth driven by multiple molecular cues. While our general concept of axon guidance remains identical, a profound evolution ofour knowledge ofthe molecular identityofthe guidance cues together with their interactions and signalling pathways occurred over the past ten years. This book proposes an exhaustive and updated view ofthe current knowledge ofthe molecular and cellular mechanisms ensuring axon growth and guidance. An introductory chapterby C. Bouquetand F. Nothias will remind the readers ofall the features ofa growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one ofthe most fantastic developmental achievements: the nervous system wiring Bibliography Includes bibliographical references and index Subject Axons -- Physiology Nervous system -- Regeneration. Nervous system -- Growth. Regeneration (Biology) Neurofibrils. Neurons. Anatomy. Life sciences. Axons. Nervous system. Physiology. Cells. Physical sciences. Nervous System Physiological Phenomena Musculoskeletal and Neural Physiological Phenomena Biological Phenomena Disciplines and Occupations Phenomena and Processes Physiological Phenomena Regeneration Cell Surface Extensions Nerve Fibers Neurons Anatomy Biological Science Disciplines Axons Growth and Development Nerve Regeneration Nervous System Physiology Cells Axons -- physiology Cellular Structures Natural Science Disciplines Nervous System -- growth & development Animal Structures anatomy. biological sciences. physiology. physical sciences. MEDICAL -- Neuroscience. PSYCHOLOGY -- Neuropsychology. Biomédecine. Sciences de la vie. Regeneration (Biology) Physiology Physical sciences Neurons Neurofibrils Nervous system Life sciences Cells Axons Anatomy Nervous system -- Growth Nervous system -- Regeneration Form Electronic book Author Bagnard, Dominique. LC no. 2007042192 ISBN 9780387767154 0387767150 9786611927004 661192700X

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