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Book Cover
Author Mobley, Arie S., author

Title Neural stem cells and adult neurogenesis / Arie S. Mobley
Edition First edition
Published London : Academic Press, 2019


Description 1 online resource
Contents Front Cover; Neural Stem Cells and Adult Neurogenesis; Copyright; Contents; Preface-The Promise of Stem Cell Research; Section I: Stem Cells; Chapter 1: History and Ethics of Stem Cells; Introduction; History of Stem Cells; Etymology of "Stem" Cells; Early Stem Cell Discoveries; Advancing Stem Cell Research; Cloning; Ethics of ESCs and Cloning; Political History of Stem Cell Research Regulation; Summary; Definitions; References; Chapter 2: Stem Cells: From Embryos to Adults; Introduction; Stem Cell Properties; Harnessing Stem Cells; Isolating ESCs; In Vivo Growth; In Vitro Growth
ESC-Like SourcesUmbilical Cord Blood Stem Cells; Amniotic Fluid Stem Cells; Somatic Stem Cells; Mesenchymal Stem Cells: Somatic Stem Cell Potency; Intestinal Stem Cells: Regulation of Proliferation; Biliary Tree Stem Cells: Discovery and Application; Summary; Definitions; References; Further Reading; Chapter 3: The Stem Cell Niche; Introduction; Functions of the Stem Cell Niche; Niche Examples; Single-Cell Niche: The Distal Tip Cell Niche of Caenorhabditis elegans Germline Stem Cells; Signaling Differentiation-Delta/Notch Pathway; Fast-Cycling Niche: Intestinal Stem Cell Niche of Drosophila
Signaling proliferation-JAK/STAT PathwaySlow-Cycling Niche: Mammalian Hair Follicle Stem Cell Niche; Signaling Quiescence-BMP and Wnt Pathway; Niches Within a Niche: Mammalian Hematopoietic Stem Cell Niche; Description of Cells/Anatomy That Make up the HSC Niche; Signaling Mobilization, Homing, and Quiescence-CXCL12/CXCR4 Pathway; Summary; Definitions; References; Further Reading; Chapter 4: Induced Pluripotent Stem Cells; Introduction; Somatic Cell Nuclear Transfer; Epigenetics; Chromatin; Histone Modification; Histone Remodeling; Transcription Factors; Induced Pluripotent Stem Cells (iPSCs)
DedifferentiationSummary; Definitions; References; Further Reading; Section II: Adult Neurogenesis; Chapter 5: Introduction to Adult Neurogenesis; Introduction; Nervous System Development; Embryonic Origin of SVZ Neural Stem Cells; Embryonic Origin of Hippocampal Neural Stem Cells; Discovery and Acceptance of Adult Neurogenesis; Neural Plasticity in the Adult Brain; Definitions; References; Further Reading; Chapter 6: Adult Neurogenesis in the Hippocampus; Anatomy of the Hippocampus; Afferents and Efferents of the Hippocampus; Phases of Adult-Born Cell Maturation
Phase 1: Stem Cell Maintenance, Activation, and Fate SpecificationPhase 2: Expansion of Intermediate Neural Progenitors; Phase 3: Migration and Initial Pruning of Newborn Granule Cells; Phase 4: Maturation and Functional Integration of Newborn Neurons; The Neurogenic Niche of the Hippocampus; Regulating the Behaviors of Adult-Born Cells; NSC Maintenance; Activation of Quiescent Cells; Proliferation of Intermediate Neural Progenitors; Regulating Differentiation; Survival; Maturation and Integration; Summary; Definitions; References; Chapter 7: Adult Neurogenesis in the Subventricular Zone
Notes Online resource; title from PDF title page (EBSCO, viewed March 5, 2019)
Subject Stem cells -- Therapeutic use
Developmental neurobiology.
Neural Stem Cells
Stem Cells -- physiology
Stem Cell Research -- ethics
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Developmental neurobiology.
Form Electronic book
ISBN 9780128110157