Title Mitochondrial dysfunction in neurodegenerative disorders / Amy K. Reeve, Eve M. Simcox, Michael R. Duchen, Doug M. Turnbull, editors

Edition Second edition Published Switzerland : Springer, 2016

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Description 1 online resource (xi, 380 pages) : illustrations (some color) Contents Part I. Mitochondria and Neurodegenerative Disease -- An Introduction to Mitochondria, Their Structure and Functions -- Part II. Mitochondrial Dysfunction: Causes and Effects? -- Neurodegeneration in Mitochondrial Disorders -- The Ageing Brain, Mitochondria and Neurodegeneration -- Mitochondrial Genes and Neurodegenerative Disease -- Mitochondrial Signalling and Neurodegeneration -- Part III. Functional Consequences of Mitochondrial Dysfunction -- Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson's Disease -- Mitochondrial Dynamics and Neurodegeneration -- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation -- Mitochondria, the Synapse, and Neurodegeneration -- Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration -- Mitochondrial Degradation, Autophagy and Neurodegenerative Disease -- The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria -- Part IV. Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease -- Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration? -- Mitochondrial Function and Dynamics Imaged In Vivo -- Part V. The Future -- Development of Treatments and Therapies to Target Mitochondrial Dysfunction -- Summary and Conclusions Summary This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research Notes Includes index Bibliography Includes bibliographical references at the end of each chapters and index Notes Online resource; title from PDF title page (SpringerLink, viewed June 21, 2016) Subject Nervous system -- Degeneration. Mitochondrial pathology. Neurodegenerative Diseases Mitochondrial Diseases -- physiopathology Biochemistry. Neurosciences. Clinical & internal medicine. Neurology & clinical neurophysiology. HEALTH & FITNESS -- Diseases -- General. MEDICAL -- Clinical Medicine. MEDICAL -- Diseases. MEDICAL -- Evidence-Based Medicine. MEDICAL -- Internal Medicine. Mitochondrial pathology Nervous system -- Degeneration Genre/Form Electronic books Form Electronic book Author Reeve, Amy Katherine, editor. Simcox, Eve M., editor Duchen, Michael R., editor Turnbull, Doug, editor. ISBN 9783319286372 3319286374 3319286358 9783319286358

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