Introduction -- Molecular control of development -- Biology of the Neuregulin/ErbB signaling network -- Neuregulins and their receptors -- Developmental functions of the Neuregulin-1/ErbB signalling pathway -- Interacting molecules -- the Sox10/ErbB connection -- NRG-1/ErbB signals and disease -- Abbreviations -- References -- Subject index
Summary
"Neuregulins are EF-like growth and differentiation factors that interact with tyrosine kimase receptors of the ErbB family. This signaling system has a wide range of functions during development of the nervous system, the heart, and the mammary gland. Furthermore, Neuregulin signals are also involved in development of human diseases including breast cancer, heart disease and the pathogenesis of Schizophrenia. This monograph reviews the biology of Neuregulins and their receptors and summarizes recent research, which has established crucial function of this signaling system during development and disease."--Jacket
Analysis
geneeskunde
medicine
biomedische wetenschappen
biomedicine
Medicine (General)
Geneeskunde (algemeen)
Bibliography
Includes bibliographical references (pages 47-65) and index
