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Author Cancer Stem Cell Workshop (2007? : Berlin-Brandenburg Academy of Sciences and Humanities)

Title Cancer stem cells : novel concepts and prospects for tumor therapy / O.D. Wiestler, B. Haendler, D. Mumberg, editors
Published Berlin ; New York : Springer, 2007
Online access available from:
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Description 1 online resource (xvi, 263 pages) : illustrations
Series Ernst Schering Foundation symposium proceedings, 0947-6075 ; 2006/5
Ernst Schering Foundation symposium proceedings ; 2006/5. 0947-6075
Contents Niche for normal and cancer stem cells / S.-I. Nishikawa, M. Osawa -- c-Myc and activated Ras during skin tumorigenesis : cooperation at the cancer stem cell level? / A. Trumpp -- Wnt signaling in stem cells and lung cancer / B. He, D.M. Jablons -- Bone morphogenetic proteins regulate tumorigenicity in human glioblastoma stem cells / S.G.M. Piccirillo, A.L. Vescovi -- Strategies to induce nuclear reprogramming / S. Eminli, R. Jaenisch, K. Hochedlinger -- The intestinal stem cell niche studied through conditional transgenesis / A.R. Clarke, V. Meniel -- The migrating cancer stem cells model--a conceptual explanation of malignant tumour progression / A. Jung, T. Brabletz, T. Kirchner -- Bone marrow niche and leukemia / A.D. Ho, W. Wagner -- Breast stem cells and cancer / G. Farnie, R.B. Clarke -- Prostate cancer stem cells : a target for new therapies / N.J. Maitland [and others] -- The hedgehog signaling network, mammary stem cells, and breast cancer : connections and controversies / M.T. Lewis, A.P. Visbal -- Strategies to eliminate cancer stem cells / R.J. Jones -- DNA repair in stem cell maintenance and conversion to cancer stem cells / S.L. Gerson, J. Reese, J. Kenyon -- Tumorigenic epithelial stem cells and their normal counterparts / V.S. Donnenberg [and others]
Summary Cancer stem cells werehave originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor, as they divide much more slowly and have very efficient drug- resistance mechanisms. Current treatments might largely spare cancer stem cells, thus leading to tumor recurrence and metastasis. The recent identification of growth and differentiation pathways responsible for cancer stem cell proliferation and survival will help in the discovery identification of novel therapeutic targets. Developing selective drugs against cancer
Bibliography Includes bibliographical references
Notes Print version record
Subject Cancer cells -- Proliferation -- Congresses.
Cancer -- Treatment -- Congresses.
Stem cells -- Congresses.
Neoplastic Stem Cells -- pathology.
Antineoplastic Agents -- pharmacology.
Neoplasms -- prevention & control.
Neoplastic Stem Cells -- drug effects.
Signal Transduction -- physiology.
Genre/Form Conference papers and proceedings.
Conference papers and proceedings.
Form Electronic book
Author Haendler, B. (Bernard)
Mumberg, D. (Dominik)
Wiestler, O. D. (Otmar D.), 1956-
Ernst Schering Research Foundation.
LC no. 2007928117
ISBN 3540708529 (alk. paper)
9783540708520 (alk. paper)