Title Autologous and cancer stem cell gene therapy / editors, Roger Bertolotti, Keiya Ozawa

Published Hackensack, NJ : World Scientific, ©2008

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Description 1 online resource (xli, 446 pages) : illustrations (chiefly color) Series Progress in gene therapy ; v. 3 Progress in gene therapy ; v. 3. Contents Introduction. Toward a universal platform for autologous stem cell gene therapy / Roger Bertolotti -- Long-term stem cell gene therapy: from current clinical random-integration achievements to stem cell gene targeting/cybridization -- I. From pioneering clinical retroviral gene therapy to experimental site-specific integrative gene therapy. 1. Stem cell gene therapy for ADA-deficiency without myelopreparative conditioning / Makoto Otsu and Tadashi Ariga. 2. Targeted insertion of transgene into a specific site on Chromosome 19 by using Adeno-Associated Virus integration machinery / Masashi Urabe [and others] 3. Herpes Simplex Virus Type 1/Adeno-Associated Virus Hybrids as site-specific integrating vectors / Cornel Fraefel [and others] -- II. Stem cell gene targeting/cybridization: toward endonuclease-boosted gene repair/alteration, custom site-specific integrative gene therapy and transmitochondrial therapy/rejuvenation. 4. Endonuclease-boosted gene targeting and cybridization for long-term stem cell gene therapy / Roger Bertolotti. 5. Cell-Free Protein-evolution systems for engineering of novel sequence-specific DNA-binding and -modifying activities / Armin Sepp, Farid Ghadessy and Yen Choo. 6. Advances in engineering homing endonucleases for gene targeting: ten years after structures / Barry L. Stoddard, Andrew M. Scharenberg and J. Monnat, Jr. 7. Gene targeting mediated by helper-dependent adenoviral vectors / Kohnosuke Mitani -- Adult pluripotent stem cells: emerging stem cell/gene therapy breakthrough. 8. Multipotent progenitor cells: a new era in stem cell mediated gene therapy? -- Cancer stem cell gene therapy. I. Cancer stem cells as breakthrough targets of cancer gene therapy. 9. Leukemia stem cells, a pioneering paradigmatic model / Daniel J. Pearce and Dominique Bonnet. 10. Mammary stem cells / Mary Shackleton [and others] 11. Human brain tumor stem cells / Sara G.M. Piccirillo and Angelo L. Vescovi. 12. CD44 as a functional cancer stem cell marker and a potential therapeutic target / Lubna Patrawala and Dean G. Tang -- II. Armed stem cells as tumor-homing vectors for cancer gene therapy. 13. Neural stem cell-mediated therapy of primary and metastatic solid tumors / Joseph Najbauer [and others] 14. Antitumor activity of adenovirally transduced CD34+ cells expressing membrane-bound TRAIL / Carmelo Carlo-Stella [and others] 15. Mesenchymal stem cells as vehicles for delivering therapeutics and oncolytic viruses / Larisa Pereboeva and Justin Roth Bibliography Includes bibliographical references and index Notes Print version record Subject Stem cells -- Therapeutic use Stem cells -- Transplantation. Gene therapy. Cancer -- Gene therapy. Autotransplantation. Autografts. Stem cells. Regenerative medicine. Stem Cells Genetic Therapy Autografts Neoplastic Stem Cells Regenerative Medicine Stem Cell Transplantation Transplantation, Autologous PSYCHOLOGY -- Psychotherapy -- General. Stem cells Regenerative medicine Autografts Autotransplantation Cancer -- Gene therapy Gene therapy Stem cells -- Transplantation Form Electronic book Author Bertolotti, R. (Roger) Ozawa, Keiya, 1953- ISBN 9789812775870 9812775870

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