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Title Ex vivo engineering of the tumor microenvironment / Amir R. Aref, David Barbie, editors
Published Cham : Humana Press, [2017]


Description 1 online resource
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents 1. Introduction to Ex Vivo Cancer Models -- 2. Patient-derived Xenografts in Oncology -- 3.Organoid Culture: Applications in Development and Cancer -- 4. Microfluidics and future of cancer diagnostics -- 5. Advancing techniques and insights in circulating tumor cell (CTC) research -- 6. The Cancer Secretome -- 7. An overview of the tumor microenvironments and future of cancer therapy
Summary This volume will outline how to recreate the tumor microenvironment, to culture primary tumors without the need for developmental priming factors, and to deliver targeted therapeutics in a manner that recapitulates pharmacokinetics in vivo. Much of what may be learned from this volume will aid in understanding many aspects of the enhanced study of tumor cell biology in a physiologic context, open new avenues for drug screening and biomarker development, and accelerate the preclinical evaluation of novel personalized medicine strategies for patients in real time
Bibliography Includes bibliographical references
Notes Online resource; title from PDF title page (EBSCO, viewed December 20, 2016)
Subject Cancer -- Molecular aspects.
Tumors -- Molecular aspects
Biological models.
Neoplastic Cells, Circulating
Tumor Microenvironment
Models, Biological
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Biological models.
Cancer -- Molecular aspects.
Form Electronic book
Author Aref, Amir R., editors.
Barbie, David, editor.
ISBN 9783319453972