| Description |
1 online resource (228 pages) : illustrations (some color) |
| Series |
Molecular biology intelligence unit |
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Molecular biology intelligence unit (Unnumbered)
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| Contents |
How the hedgehog outfoxed the crab: interference with HEDGEHOG-GLI signaling as anti-cancer therapy? / Ariel Ruiz i Altaba -- The patched receptor: switching on/off the hedgehog signaling pathway / Luis Quijada [and others] -- Making a morphogenetic gradient / Henk Roelink -- Spatial and temporal regulation of hair follicle progenitors by hedgehog signaling / Anthony E. Oro -- Mode of PTCH1/Ptch1-associated tumor formation: insights from mutant Ptch1 mice / Heidi Hahn -- Basal cell carcinomas, hedgehog signaling, and the Ptch1+/- mouse / Ervin Epstein, Jr. -- GLI genes and their targets in epidermal development and disease / Fritz Aberger and Anna-Maria Frischauf -- Splitting hairs: dissecting the roles of Gli activator and repressor frunctions during epidermal development and disease / Pleasantine Mill and Chi-Chung Hui -- Shh expression in pulmonary injury and disease / Paul M. Fitch [and others] |
|
Human correlates of GL13 function / Leslie G. Biersecker -- From oligodactyly to polydactyly: role of Shh and Gli3 in limb morphogenesis / Chin Chiang -- The genetics of Indian hedgehog / M. Elizabeth McCready and Dennis E. Bulman -- Sonic hedgehog signaling in craniofacial development / Dwight Cordero, Minal Tapadia and Jill A. Helms -- Important role of Shh controlling Gli3 functions during the dorsal-ventral patterning of the telencephalon / Jun Motoyama and Kazushi Aoto -- Regulation of early events in cell cycle progression by hedgehog signaling in CNS development and tumorigenesis / Anna Marie Kenney and David H. Rowitch -- Modulating the hedgehog pathway in diseases / Frederic J. de Sauvage and Lee L. Rubin -- Hedgehog signaling in endodermally derived tumors / Marina Pasca di Magliano and Matthias Hebrok |
| Summary |
Annotation Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies |
| Analysis |
neoplasms |
|
ontogenie |
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ontogeny |
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biomedische wetenschappen |
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biomedicine |
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humane genetica |
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human genetics |
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Medicine (General) |
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Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer e-books |
| Subject |
Cellular signal transduction.
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Oncogenes.
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Tumor proteins.
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Signal Transduction -- physiology
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Signal Transduction
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Oncogenes
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Neoplasm Proteins
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Oncogene Proteins -- metabolism
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Transcription Factors -- metabolism
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MEDICAL -- Oncology.
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HEALTH & FITNESS -- Diseases -- Cancer.
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Tumor proteins.
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Signal Transduction -- physiology.
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Oncogene Proteins -- metabolism.
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Transcription Factors -- metabolism.
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Cellular signal transduction.
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Oncogenes.
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Biomédecine.
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Sciences de la vie.
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Cellular signal transduction
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Oncogenes
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Tumor proteins
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| Form |
Electronic book
|
| LC no. |
2005028604 |
| ISBN |
9780387337777 |
|
0387337776 |
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0387257845 |
|
9780387257846 |
|
6610949328 |
|
9786610949328 |
|
