| Description |
1 online resource |
| Series |
SpringerBriefs in molecular science, Biometals, 2191-5407 |
|
SpringerBriefs in molecular science. Biometals.
|
| Contents |
Introduction to the Book / B. Rowe Byers -- A History of Iron Metabolism in the Mycobacteria / Colin Ratledge -- Mycobacterial Iron Acquisition Mechanisms / B. Rowe Byers -- Siderocalin Combats Mycobacterial Infections / Benjamin E. Allred, Allyson K. Sia -- Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis / Raúl E. Juárez-Hernández, Helen Zhu |
| Summary |
Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates |
| Analysis |
Life sciences |
|
Emerging infectious diseases |
|
RNA-ligand interactions |
|
Microbiology |
|
Inorganic Chemistry |
|
Infectious Diseases |
|
levenswetenschappen |
|
eiwitten |
|
proteins |
|
liganden |
|
ligands |
|
organische scheikunde |
|
organic chemistry |
|
microbiologie |
|
anorganische scheikunde |
|
infectieziekten |
|
Biology (General) |
|
Biologie (algemeen) |
| Notes |
Includes index |
| Bibliography |
Cludes bibliographical references |
| Notes |
Print version record |
| Subject |
Mycobacteria -- Metabolism
|
|
Iron -- Metabolism.
|
|
Iron -- metabolism
|
|
Mycobacterium -- metabolism
|
|
SCIENCE -- Life Sciences -- Biology.
|
|
SCIENCE -- Life Sciences -- Microbiology.
|
|
Iron -- Metabolism.
|
| Form |
Electronic book
|
| Author |
Byers, B. Rowe
|
| ISBN |
9783319003030 |
|
3319003038 |
|
331900302X |
|
9783319003023 |
|
