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Title Systems biology of tuberculosis / Johnjoe McFadden, Dany J.V. Beste, Andrzej M. Kierzek, editors
Published New York : Springer, [2013]


Description 1 online resource (xv, 226 pages) : illustrations (chiefly color)
Contents Modeling Mycobacterium tuberculosis H37Rv in silico / Neema Jamshidi, Aarash Bordbar, Bernhard Palsson -- Software platform for metabolic network reconstruction of Mycobacterium tuberculosis / Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai -- Probing gene regulatory networks to decipher host-pathogen interactions / Kanury V.S. Rao, Dhiraj Kumar, Shekhar C. Mande -- Metabolism of Mycobacterium tuberculosis / Dany J.V. Beste, Johnjoe McFadden Ph. D. -- Protein-protein interaction in the -omics era: understanding Mycobacterium tuberculosis function / Adrie J.C. Steyn, D. Mai, V. Saini, A. Farhana -- Host-pathogen interactions / Simon J. Waddell, Axel von Kamp, Steffen Klamt -- A systems biology approach for understanding granuloma formation and function in tuberculosis / Mohammad Fallahi-Sichani Ph. D., Simeone Marino Ph. D. -- Stochastic gene expression in bacterial pathogens: a mechanism for persistence? / Andrea Rocco Ph. D., Andrzej Kierzek Ph. D. -- Drug discovery / Nagasuma Chandra -- Immunological biomarkers for tuberculosis: potential for a combinatorial approach / Richard Pine, Yuri Bushkin, Maria Laura Gennaro
Summary "Tuberculosis remains one of the world's biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century's first new science, systems biology, to the study of tuberculosis. After introducing the basic principles of systems biology, successive chapters describe how systems-based approaches provide new insights into gene regulation, metabolism, protein-protein interaction, host-pathogen interactions, the immune response, persistence, drug treatment and diagnosis of tuberculosis. This book will be an invaluable aid to anyone interested in exploring how the latest science is helping us to understand this ancient disease"--Publisher's description
Analysis Life sciences
Biological models
Systems Biology
Medical Microbiology
Bibliography Includes bibliographical references and index
In Springer eBooks
Subject Systems biology.
Tuberculosis -- Etiology.
Systems Biology
Tuberculosis -- etiology
Mycobacterium tuberculosis -- genetics
Mycobacterium tuberculosis -- physiology
Systems Biology -- methods
MEDICAL -- Oncology.
Systems biology
Tuberculosis -- Etiology
Form Electronic book
Author McFadden, Johnjoe, editor
Beste, Dany J. V., editor.
Kierzek, Andrzej, editor.
ISBN 9781461449669