| Description |
1 online resource (248 pages) |
| Series |
Current topics in microbiology and immunology ; v. 374 |
|
Current topics in microbiology and immunology ; 374.
|
| Contents |
Genetic Diversity in Mycobacterium tuberculosis / Sebastien Gagneux -- DNA Metabolism in Mycobacterial Pathogenesis / Digby F. Warner, Tone Tønjum and Valerie Mizrahi -- Molecular Biology of Drug Resistance in Mycobacterium tuberculosis / Tasha Smith, Kerstin A. Wolff and Liem Nguyen -- Antimicrobial Efflux Pumps and Mycobacterium tuberculosis Drug Tolerance: Evolutionary Considerations / John D. Szumowski, Kristin N. Adams, Paul H. Edelstein and Lalita Ramakrishnan -- Getting Across the Cell Envelope: Mycobacterial Protein Secretion / Aniek D. van der Woude, Joen Luirink and Wilbert Bitter -- A Single-Cell Perspective on Non-Growing but Metabolically Active (NGMA) Bacteria / Giulia Manina and John D. McKinney -- Mycobacterium Tuberculosis Metabolism and Host Interaction: Mysteries and Paradoxes / Sabine Ehrt and Kyu Rhee -- Surviving the Macrophage: Tools and Tricks Employed by Mycobacterium tuberculosis / Rajesh Jayachandran, Somdeb BoseDasgupta and Jean Pieters -- Host-Pathogen Interactions During Mycobacterium tuberculosis infections / Sarah A. Stanley and Jeffery S. Cox |
| Summary |
Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host's innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts |
| Notes |
English |
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Online resource; title from PDF title page (ebrary, viewed January 13, 2014) |
| Subject |
Mycobacterium tuberculosis.
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Immunology.
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Tuberculosis.
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Mycobacterium tuberculosis -- pathogenicity
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Mycobacterium tuberculosis -- metabolism
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Host-Pathogen Interactions
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Mycobacterium tuberculosis
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Allergy and Immunology
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Tuberculosis
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Tuberculosis, Pulmonary
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Immunology
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Mycobacterium tuberculosis
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Tuberculosis
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| Form |
Electronic book
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| Author |
McKinney, John D.
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|
Pieters, Jean (Professor of Biochemistry)
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| ISBN |
9783642402326 |
|
3642402321 |
|
3642402313 |
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9783642402319 |
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