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Book Cover
Author Winder, Steve J

Title Molecular Mechanisms of Muscular Dystrophies
Published London : Landes Bioscience, 2006


Description 1 online resource (248 pages)
Series Molecular Biology Intelligence Unit
Molecular biology intelligence unit.
Contents COVER; Title Page. Molecular Mechanisms of Muscular Dystrophies; Copyright ©2006; Table of Contents; Editor and Contributors; Foreword; Acknowledgments; CHAPTER 1. Structure and Function of the Dystrophin-Glycoprotein Complex; CHAPTER 2. The Structure and Function of Dystrophin; CHAPTER 3. Utrophin in the Therapy of Duchenne Muscular Dystrophy; CHAPTER 4. Syntrophin: A Molecular Adaptor Conferring a Signaling Role to the Dystrophin-Associated Protein Complex; CHAPTER 5. Molecular and Functional Diversity of Dystrobrevin-Containing Complexes
CHAPTER 6. Commonalities and Differences in Muscular Dystrophies: Mechanisms and Molecules Involved in Merosin-Deficient Congenital Muscular DystrophyCHAPTER 7. Glycosylation and Muscular Dystrophy; CHAPTER 8. Overview of the Limb-Girdle Muscular Dystrophies and Dysferlinopathy; CHAPTER 9. Caveolin-3 and Limb-Girdle Muscular Dystrophy; CHAPTER 10. The Sarcoglycans; CHAPTER 11. Sarcomeric Proteins in LGMD; CHAPTER 12. Lamins and Emerin in Muscular Dystrophy: The Nuclear Envelope Connection
CHAPTER 13. Distinct Mechanisms Downstream of the Repeat Expansion Are Implicated in the Molecular Basis of Myotonic Dystrophy Type 1CHAPTER 14. Spinal Muscular Atrophy; CHAPTER 15. The Pathophysiological Role of Impaired Calcium Handling in Muscular Dystrophy; CHAPTER 16. Cell Adhesion and Signalling in the Muscular Dystrophies; CHAPTER 17. Gene Therapies for Muscular Dystrophies; CHAPTER 18. Cell Therapies for Muscular Dystrophy; INDEX; A-F; G-N; P-Z; BACK COVER
Summary The first detailed study of the clinical features, hereditary nature and pathology of muscular dystrophy is attributed to Edward Meryon, an English physician, who published his findings in 1852. Yet it was more than 130 years later that the responsible gene for the commonest form of dystrophy, Duchenne muscular dystrophy, was identified and characterised. Subsequently the genes for many other forms of dystrophy have been identified, and it is estimated that there are now approaching 40 such disorders, though some of these are very rare. However once the gene for Duchenne dystrophy had been ide
Bibliography Includes bibliographical references at the end of each chapters and index
Notes Print version record
Subject Muscular dystrophy -- Molecular aspects
Dystrophin -- genetics
Muscular Dystrophies -- genetics
Dystrophin-Associated Proteins -- genetics
MEDICAL -- Orthopedics.
HEALTH & FITNESS -- Diseases -- Musculoskeletal.
MEDICAL -- Rheumatology.
Form Electronic book
ISBN 9781587063947