Title Airway smooth muscle in asthma and COPD : biology and pharmacology / edited by Kian Fan Chung

Published Chichester ; Hoboken, N.J. : John Wiley & Sons, ©2008

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Description 1 online resource (xiv, 312 pages, 4 unnumbered pages of plates) : illustrations (some color) Contents Airway Smooth Muscle; Contents; List of Contributors; 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma; 2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction; 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness; 4 Airway smooth muscle phenotypic and functional plasticity; 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass; 6 Airway smooth muscle bidirectional interactions with extracellular matrix 7 Airway smooth muscle interaction with mast cells8 Airway smooth muscle synthesis of inflammatory mediators; 9 Airway smooth muscle in experimental models; 10 Altered properties of airway smooth muscle in asthma; 11 The airway smooth muscle in chronic obstructive pulmonary disease (COPD); 12 Glucocorticoid actions on airway smooth muscle; 13 B2-Adrenergic receptors: effects on airway smooth muscle; 14 Asthma treatments: effects Summary In this book, leading researchers in medicine and molecular pharmacology explain the cellular mechanisms that control airway smooth muscle. The means by which these are disrupted in disease, and the pharmacologic strategies by which they may be modified are discussed and future therapeutic interventions are identified. . Aimed at specialists in pulmonology, this volume provides the clinician with the most up to date information on one of the core physiological processes in airway disease, and offers insights into current and future approaches to management. : Authoritative update on key mech Bibliography Includes bibliographical references and index Notes Print version record Subject Respiratory muscles -- Physiology Smooth muscle -- Physiology Smooth muscle -- Molecular aspects Respiratory agents. Respiratory organs -- Diseases -- Treatment Respiratory therapy. Asthma -- physiopathology Pulmonary Disease, Chronic Obstructive -- physiopathology Muscle, Smooth -- drug effects Muscle, Smooth -- physiopathology Respiratory System -- drug effects Respiratory System -- physiopathology Respiratory System Agents MEDICAL -- Physiology. SCIENCE -- Life Sciences -- Human Anatomy & Physiology. Respiratory agents Respiratory muscles -- Physiology Respiratory organs -- Diseases -- Treatment Respiratory therapy Smooth muscle -- Physiology Form Electronic book Author Chung, K. Fan, 1951- ISBN 9780470754214 0470754214 9780470060667 0470060662

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