1. Overview of airway mucus clearance -- 2. The biophysical properties of mucus -- 3. Regulation of airway mucus secretion -- 4. Outcomes for trials of mucoactive therapy -- 5. Adherence with the use of clearance techniques -- 6. Taxonomy of mucoactive medications -- 7. Mucoactive drug delivery -- 8. Expectorants -- 9. Mucolytics and mucus clearance -- 10. Modulation of mucociliary function by drugs and other agents -- 11. Mucokinetic agents and surfactant -- 12. Mucoregulatory medications -- 13. Hyperosmolar solutions and ion channel modifiers -- 14. Mucoactive agents and the upper airway -- 15. Issues on regulatory approval of mucoactive drugs -- 16. Airway-clearance techniques individually tailored to each patient -- 17. High-frequency oscillation, PEP, and flutter -- 18. Pediatric mucus clearance by chest physiotherapy: principles and practice -- 19. Postoperative mucus clearance -- 20. Management of airway secretions in patients with severe respiratory muscle dysfunction
Summary
This single-source reference provides an up-to-date exploration of current medications and devices used for the clearance of mucus from the lungs while simultaneously providing the latest research and studies to clearly guide scientists studying the pathophysiology of airway inflammation and mucus clearance, clinicians and therapists treating patients with chronic lung disease, and researchers developing new medications and devices to enhance airway clearance
