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Monooxygenase, Cytochrome P-450-Dependent -- See Cytochrome P-450 Enzyme System


A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism
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Monooxygenase, Sparteine -- See Cytochrome P-450 CYP2D6


A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population
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  Monooxygenases -- 2 Related Subjects   2
Monooxygenases. : Modern biooxidation : enzymes, reactions and applications / edited by Rolf D. Schmid and Vlada B. Urlacher  2007 1
Monooxygenases -- Physiological effect : Cytochrome P450 function and pharmacological roles in inflammation and cancer / edited by James P. Hardwick  2015 1
Monooxygenases -- Technique. : Cytochrome P450 / edited by Michael R. Waterman, Eric F. Johnson  2002 1
Monooxygenases -- Therapeutic use : Cytochrome P450 function and pharmacological roles in inflammation and cancer / edited by James P. Hardwick  2015 1
Monophonic chansons.   12
Monophonic chansons -- 500-1400 -- History and criticism : Chromatic beauty in the late medieval chanson : an interpretation of manuscript accidentals / Thomas Brothers  1997 1
 

Monophosphate, Adenosine Cyclic -- See Cyclic AMP


An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH
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Monophosphate, Guanosine Cyclic -- See Cyclic GMP


Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)
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  Monophysites -- 3 Related Subjects   3
Monophysites.   4
Monophysites -- Controversial literature -- Early works to 1800   2
Monophysites -- Middle East -- History : Asceticism and society in crisis : John of Ephesus and the Lives of the Eastern saints / Susan Ashbrook Harvey  1990 1
Monophysitismus   2
 

Monoplegia -- See Hemiplegia


Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body
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Monoplegias -- See Hemiplegia


Severe or complete loss of motor function on one side of the body. This condition is usually caused by BRAIN DISEASES that are localized to the cerebral hemisphere opposite to the side of weakness. Less frequently, BRAIN STEM lesions; cervical SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; and other conditions may manifest as hemiplegia. The term hemiparesis (see PARESIS) refers to mild to moderate weakness involving one side of the body
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Monoplegic Cerebral Palsies -- See Cerebral Palsy


A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
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Monoplegic Cerebral Palsy -- See Cerebral Palsy


A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
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Monoplegic Infantile Cerebral Palsy -- See Cerebral Palsy


A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)
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Monopol   5
Monopoles.   4
 

Monopoles, Magnetic -- See Magnetic monopoles


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Italy -- Monopoli : Participation and beliefs in popular religiosity : an empirical-theological exploration among Italian Catholics / by Francesco Zaccaria  2010 1
Monopoli (Italy) -- Religious life and customs : Participation and beliefs in popular religiosity : an empirical-theological exploration among Italian Catholics / by Francesco Zaccaria  2010 1
Monopolie.   4
  Monopolies -- 11 Related Subjects   11
Monopolies.   141
Monopolies -- Australia.   15
Monopolies -- Australia -- Congresses. : Monopolies, mergers and restrictive trade practices : an examination of federal legislation [papers presented and discussed at a Conference held at the Australian National University on Saturday 12th August 1972] / compiled by L. Moran  1972 1
Monopolies -- Australia -- Law and legislation. : Mergers, monopolies and acquisitions : adequacy of existing legislative controls / report by the Senate Standing Committee on Legal and Constitutional Affairs  1991 1
Monopolies -- Australia -- New South Wales. : Facts behind the Liquor Commission / by "Peter" & "George"  1959? 1
Monopolies -- Case studies   3
Monopolies -- Cases : Monopoly and trade restraint cases : including conspiracy, injunction, quo warranto, pleading and practice and evidence / by John Lewson of the Chicago bar  1908 1
Monopolies -- China : The Chinese anti-monopoly law : new developments and empirical evidence / edited by Michael Faure, Xinzhu Zhang  2013 1
Monopolies -- China -- Econometric models : De-monopolization toward long-term prosperity in China / Ashvin Ahuja  2012 1
Monopolies -- Czechoslovakia : Nástroj prospěšný, či vražedný? : proces monopolizace na trhu stavebních hmot Předlitavska a meziválečného Československa / Tomáš Gecko  2021 1
Monopolies -- Econometric models   3
Monopolies -- Europe : Efficient monopolies : the limits of competition in the European property insurance market / Thomas von Ungern-Sternberg  2004 1
Monopolies -- Europe -- Cross-cultural studies : Efficient monopolies : the limits of competition in the European property insurance market / Thomas von Ungern-Sternberg  2004 1
Monopolies -- European Union countries.   3
Monopolies -- Germany   2
 

Monopolies, Government -- See Government monopolies


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Monopolies -- Government policy   2
Monopolies -- Government policy -- United States   2
Monopolies -- Great Britain   11
Monopolies -- Great Britain -- History : The English patents of monopoly / by William Hyde Price  1913 1
Monopolies -- Great Britain -- History -- 19th century : Breaking into the monopoly : provincial merchants and manufacturers' campaigns for access to the Asian market, 1790-1833 / by Yukihisa Kumagai  2012 1
Monopolies -- Great Britain -- History -- 20th century.   2
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