Title Mass spectrometry imaging of small molecules / edited by Lin He

Published New York, NY : Humana Press, [2015] ©2015

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Description 1 online resource (xi, 213 pages) : illustrations (some color) Series Methods in Molecular Biology, 1940-6029 ; 1203 Methods in molecular biology (Clifton, N.J.) ; v. 1203. 1064-3745 Contents Current status and future prospects of mass spectrometry imaging of small molecules / Victoria L. Brown and Lin He -- Sample preparation for 3D SIMS chemical imaging of cells / Nicholas Winograd and Anna Bloom -- TOF-SIMS imaging of lipids on rat brain sections / David Touboul and Alain Brunelle -- MALDI-MS-assisted molecular imaging of metabolites in legume plants / Erin Gemperline and Lingjun Li -- MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections / David Touboul and Alain Brunelle -- Multiplex MALDI-MS imaging of plant metabolites using a hybrid MS system / Andrew R. Korte [and 3 others] -- DESI imaging of small molecules in biological tissues / Elaine C. Cabral and Demian R. Ifa -- Desorption electrospray ionization imaging of small organics on mineral surfaces / Rachel V. Bennett and Facundo M. Fernández-- Imaging of plant materials using indirect desoprtion electrospray ionization mass spectrometry / Christian Janfelt -- Imaging of lipids and metabolites using nanospray desorption electropray ionization mass spectrometry / Ingela Lanekoff and Julia Laskin -- Electrospray laser desorption ionization (ELDI) mass spectrometry for molecular imaging of small molecules on tissues / Min-Zong Huang, Siou-Sian Jhang, and Jentaie Shiea -- Automated cell-by-cell tissue imaging and single-cell analysis for targeted morphologies by laser ablation electrospray ionization mass spectrometry / Hang Li [and 4 others] -- Laser ablation sample transfer for mass spectrometry imaging / Sung-Gun Park and Kermit K. Murray -- Nanostructure imaging mass spectrometry : the role of fluorocarbons in metabolite analysis and yoctomole level sensitivity / Michael E. Kurczy [and 3 others] -- Nanostructure-initiator mass spectrometry (NIMS) for molecular mapping of animal tissues / Tara N. Moening, Victoria L. Brown, and Lin He -- Nanoparticle-assisted laser desorption/ionization for metabolite imaging / Michihiko Waki [and 4 others] -- Matrix-enhanced surface-assisted laser desorption/ionization mass spectrometry (ME-SALDI-MS) for mass spectrometry imaging of small molecules / Victoria L. Brown, Qiang Liu, and Lin He -- Laser desorption postionization mass spectrometry imaging of biological targets / Artem Akhmetov, Chhavi Bhardwaj, and Luke Hanley -- Data processing and analysis for mass spectrometry imaging / Jiangjiang Liu, Xingchuang Xiong, and Zheng Ouyang Summary Mass Spectroscopy Imaging (MSI) has emerged as an enabling technique to provide insight into the molecular entities within cells, tissues and whole-body samples and to understand inherent complexities within biological metabolomes In Mass Spectrometry Imaging of Small Molecules, experts in the MSI field present techniques for 2D and 3D visualization and quantification of a wide array of small molecular species present in biologically relevant samples Chapters provide detailed operational instructions from sample preparation to method selection, from comparative quantification to structural identification, and from data collection to visualization of small molecule mapping in complex samples Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls Authoritative and easily accessible, Mass Spectrometry Imaging of Small Molecules aims to bring the rapidly maturing methods of metabolic imaging to life science researchers and to minimize technical intimidation in adapting new technological platforms in biological research Analysis geneeskunde medicine volksgezondheid public health spectrometrie spectrometry microscopie microscopy afbeelden imagery radiologie radiology biologische technieken biological techniques Medicine (General) Geneeskunde (algemeen) Bibliography Includes bibliographical references and index Notes Online resource; title from PDF title page (SpringerLink, viewed November 24, 2014) Subject Mass spectrometry -- Laboratory manuals Molecular weights. Mass Spectrometry -- methods Molecular Imaging -- methods Molecular Weight molecular weight. Biology, life sciences. Radiology. Spectrum analysis, spectrochemistry, mass spectrometry. Medical -- Biochemistry. Science -- Life Sciences -- General. Science -- Spectroscopy & Spectrum Analysis. Molecular weights Mass spectrometry Genre/Form Laboratory manuals Laboratory manuals. Manuels de laboratoire. Form Electronic book Author He, Lin (Nanotechnologist), editor. ISBN 9781493913572 1493913573 1493913565 9781493913565

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