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E-book
Author Junk, Matthias J. N

Title Assessing the functional structure of molecular transporters by EPR spectroscopy / Matthias J.N. Junk
Published Berlin ; New York : Springer, ©2012

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Description 1 online resource (xvi, 212 pages) : illustrations
Series Springer theses
Springer theses.
Contents Electron Paramagnetic Resonance Theory -- The Functional Structure of Human Serum Albumin -- Copper Complexes of Star-Shaped Cholic Acid Oligomers with 1,2,3-Triazole Moieties -- Nano-Inhomogeneities in Structure and Reactivity of Thermoresponsive Hydrogels -- Thermoresponsive Spin-Labeled Hydrogels as Separable DNP Polarizing Agents -- Local Nanoscopic Heterogeneities in Thermoresponsive Dendronized Polymers
Summary In his thesis, Matthias Junk takes an innovative approach to assess the local structure and dynamics of biological and synthetic amphiphilic macromolecules capable of transporting small molecules. Replacing the latter with stable radicals, he uses state-of-the-art electron paramagnetic resonance (EPR) spectroscopy to describe the highly relevant transport function from the viewpoint of the guest molecules. Such, he demonstrates that the functional structure of human serum albumin in solution significantly differs from its crystal structure - a consequence of the protein's adaptability to host various endogenous compounds and drug molecules. Further, he shows that the thermal collapse of thermoresponsive hydrogels and dendronized polymers leads to static and dynamic heterogeneities on the nanoscale. These heterogeneities bear consequences for the material's hosting properties and enable unforeseen complex catalytic functionalities
Analysis Chemistry
Spectroscopy
Chemistry, Physical organic
Polymers
Polymer Sciences
Spectroscopy/Spectrometry
Soft and Granular Matter, Complex Fluids and Microfluidics
Physical Chemistry
Notes "Doctoral thesis accepted by Johannes Gutenberg-Universität Mainz, Mainz, Germany."
Ph. D. Johannes Gutenberg-Universität Mainz
Bibliography Includes bibliographical references
Subject Electron paramagnetic resonance spectroscopy.
Molecule-molecule collisions.
Electron Spin Resonance Spectroscopy
SCIENCE -- Chemistry -- Analytic.
Science des matériaux.
Chimie.
Electron paramagnetic resonance spectroscopy
Molecule-molecule collisions
Genre/Form dissertations.
Academic theses
Academic theses.
Thèses et écrits académiques.
Form Electronic book
ISBN 9783642251351
3642251358