| Description |
1 online resource (xiii, 252 pages) : illustrations |
| Contents |
1. The Early Days of Paleogenomics, Connecting Molecules to the Planet; 2. Ancestral Sequence Reconstruction as a Tool to Understand Natural History and Guide Synthetic Biology: Realizing and Extending the Vision of Zuckerkandl and Pauling; 3. Linking Sequence to Function in Drug Design with Ancestral Sequence Reconstruction; 4. Probabilistic Models and Their Impact on the Accuracy of Reconstructed Ancestral Sequences; 5. Probabilistic Ancestral Sequences Based on the Markovian Model of Evolution- Algorithms and Applications; 6. Estimating the History of Mutations on a Phylogeny; 7. Coarse Projections of the Protein-Mutational Fitness Landscape; 8. Dealing with Uncertainty in Ancestral Sequence Reconstruction: Sampling from the Posterior Distribution; 9. Evolutionary Properties of Sequences and Ancestral State Reconstruction; 10. Reconstructing the Ancestral Eukaryote- Lessons from the Past; 11. Using Ancestral Sequence Inference to Determine the Trend of Functional Divergence After Gene Duplication; 12. Reconstruction of Ancestral Proteomes; 13. Computational Reconstruction of Ancestral Genomic Regions from Evolutionarily Conserved Gene Clusters; 14. Experimental Resurrection of Ancient Biomolecules: Gene Synthesis, Heterologous Protein Expression, and Functional Assays; 15. Dealing with Model Uncertainty in Reconstructing Ancestral Proteins in the Laboratory: Examples from Ancestral Visual Pigments and GFP-like Proteins; 16. Unraveling the Evolution of Complexity by Resurrecting Ancient Genes; 17. A Thermophilic Last Universal Ancestor Inferred from its Estimated Amino Acid Composition; 18. The Resurrection of Ribonucleases from Mammals. From Ecology to Medicine; 19. Evolution of Specificity and Diversity |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Nucleotide sequence.
|
|
Evolutionary genetics.
|
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SCIENCE -- Life Sciences -- Molecular Biology.
|
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Evolutionary genetics
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Nucleotide sequence
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| Form |
Electronic book
|
| Author |
Liberles, David A., editor.
|
| ISBN |
9781435623712 |
|
1435623711 |
|
