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Author Kareva, Irina, author

Title Understanding cancer from a systems biology point of view : from observation to theory and back / Irinia Kareva
Published London, United Kingdom : Academic Press, an imprint of Elsevier, 2018
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Description 1 online resource
Contents Front Cover; UNDERSTANDING CANCER FROM A SYSTEMS BIOLOGY POINT OF VIEW; UNDERSTANDING CANCER FROM A SYSTEMS BIOLOGY POINT OF VIEW: From Observation to Theory and Back; Copyright; Dedication; CONTENTS; 1 -- Introduction; A PRIMER ON MATHEMATICAL MODELING: PREDATOR-PREY; ESTIMATING PARAMETERS; 2 -- Tumor Dormancy; INTRODUCTION; MODELING PARAMETRICALLY HETEROGENEOUS POPULATIONS: PARAMETER DISTRIBUTION TECHNIQUE; PARAMETERS AND DISTRIBUTIONS; Choice of Initial Distribution; Parametrically Heterogeneous Malthusian Growth; Parametrically Heterogeneous Logistic Growth
ORIGINS OF MAXIMUM TOLERATED DOSE PROTOCOL FOR CHEMOTHERAPY ADMINISTRATIONWHAT DO WE NOW KNOW ABOUT MOST SOLID TUMORS?; CANCER AS AN ECOSYSTEM: LESSONS FROM CONSERVATION BIOLOGY; METRONOMIC (MAINTENANCE) CHEMOTHERAPY AS A WAY TO TARGET TUMOR MICROENVIRONMENT; DECREASED ANGIOGENESIS; IMPROVED ANTITUMOR IMMUNITY; DECREASED THERAPEUTIC RESISTANCE; CLINICAL TRIALS; POTENTIAL SYNERGY BETWEEN IMMUNOTHERAPY AND CHEMOTHERAPY; CYTOTOXIC T-LYMPHOCYTE ANTIGEN-4 INHIBITION; PD-1, PD-L1, AND PD-L2 INHIBITION; COMBINATION: METRONOMIC CHEMOTHERAPY AND CHECKPOINT INHIBITORS
Parametrically Heterogeneous Allee GrowthDistribution of Growth Parameter c; Distribution of Carrying Capacity l; Distribution of Parameter m; PRIMARY DORMANCY, METASTATIC DORMANCY, BOTH OR NEITHER?; GETTING BACK TO THE QUESTION; REFERENCES; 3 -- Cancer Immunoediting: A Process Driven by Metabolic Competition as a Predator-Prey-Shared Resource Type Model; BACKGROUND; MODEL DESCRIPTION; MODEL INVESTIGATION: USING THE MODEL TO ANSWER QUESTIONS; Brief Introduction to Dynamical Regimes; Aerobic and Glycolytic Tumor Cells Can Cooperate to Defeat the Immune System
USING MATHEMATICAL MODELING FOR HYPOTHESIS TESTINGMODEL DESCRIPTION; PARAMETER ESTIMATION; NORMAL BLOOD VESSEL FORMATION; The Effects of Tumor-Induced Inflow of Angiogenesis Regulators; Comparison With Previously Reported Experimental Data; SUMMARY; REFERENCES; 5 -- Angiogenesis Regulators as a Possible Key to Accelerated Growth of Secondary Tumors Following Primary Tumor Res ...; INTRODUCTION; Model Description; SENSITIVITY ANALYSIS; RESULTS; Time to Surgery and Time to Metastases; THERAPEUTIC IMPLICATIONS; REFERENCES; 6 -- Cancer as a Systemic Disease That Requires a Systemic Approach
WE WROTE AND ANALYZED THE MODEL. NOW WHAT?PHARMACOKINETIC AND PHARMACODYNAMIC MODELING; Drug Pharmacokinetics; INCLUDING THE EFFECTS OF VARIOUS IMMUNOTHERAPEUTIC INTERVENTIONS; Increased Immune Stimulation Can Be Sufficient to Control Tumor Size but not to Eliminate It; High Death Rates of Immune Cells Can Promote Tumor Growth; GETTING BACK TO THE QUESTION; REFERENCES; 4 -- Blood Vessel Formation and Pathological Angiogenesis as Mitigated by Competing Angiogenesis Regulators; INTRODUCTION; NORMAL BLOOD VESSEL FORMATION; WHAT HAPPENS IN TUMORS?
Notes Includes index
Online resource; title from PDF title page (EBSCO, viewed February 15, 2018)
Subject Neoplasms -- genetics
Neoplasms -- physiopathology
Systems Biology -- trends
Computational Biology -- trends
Models, Theorectical
Cancer -- Molecular aspects
Systems biology
Cancer -- Molecular aspects.
SCIENCE / Life Sciences / Anatomy & Physiology.
Systems biology.
Form Electronic book
ISBN 012813674X (electronic bk.)
9780128136744 (electronic bk.)
(print)