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Title Transgenic and knockout models of neuropsychiatric disorders / edited by Gene S. Fisch, Jonathan Flint
Published Totowa, N.J. : Humana Press, ©2006


Description 1 online resource (xii, 296 pages) : illustrations
Series Contemporary clinical neuroscience
Contemporary clinical neuroscience.
Contents Transgenic and knockout models of psychiatric disorders: introduction, history, and assessment / Gene S. Fisch -- Transgenic mouse models and human psychiatric disease / Jonathan Flint -- Transgenic and knockout mouse models: the problem of language / Linda J. Hayes and Diana Delgado -- If only they could talk: genetic mouse models for psychiatric disorders / Trevor Humby and Lawrence Wilkinson
Spinocerebellar ataxia type 1: lessons from modeling a movement disease in mice / Harry T. Orr -- Mouse models of hereditary mental retardation / Hans Welzl [and others] -- How can studies of animals help to uncover the roles of genes implicated in human speech and language disorders? / Simon E. Fisher -- Animal models of autism: proposed behavioral paradigms and biological studies / Thomas Bourgeron, Stéphane Jamain, and Sylvie Granon
Genetic mouse models of psychiatric disorders: advantages, limitations, and challenges / Joseph A. Gogos and Maria Karayiorgou -- Animal models of psychosis / Stephen I. Deutsch [and others] -- Animal models of anxiety: the ethological perspective / Robert Gerlai, Robert Blanchard, and Caroline Blanchard -- Modeling human anxiety and depression in mutant mice / Andrew Holmes and John F. Cryan -- Mutant mouse models of bipolar disorder: are there any? / Anneloes Dirks, Lucianne Groenink, and Berend Olivier
Summary Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language. Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today
Bibliography Includes bibliographical references and index
In Springer e-books
Subject Mental illness -- Animal models.
Mental illness -- Genetic aspects.
Transgenic mice -- Genetics
Animal experimentation.
Diseases -- Animal models.
Psychology, Experimental.
Mental Disorders -- genetics
Mental Disorders -- physiopathology
Animal Experimentation
Disease Models, Animal
Mice, Transgenic -- genetics
Psychology, Experimental
HEALTH & FITNESS -- Diseases -- Nervous System (incl. Brain)
MEDICAL -- Neurology.
Mental illness -- Genetic aspects.
Transgenic mice -- Genetics.
Mental Disorders -- genetics.
Mental Disorders -- physiopathology.
Animal experimentation.
Disease Models, Animal.
Mice, Transgenic -- genetics.
Psychology, Experimental.
Mental illness -- Animal models.
Sciences de la vie.
Psychology, Experimental
Diseases -- Animal models
Animal experimentation
Mental illness -- Animal models
Mental illness -- Genetic aspects
Form Electronic book
Author Fisch, Gene S.
Flint, Jonathan.
ISBN 1588295079