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Title Metabolomics tools for natural product discovery : methods and protocols / edited by Ute Roessner and Daniel Anthony Dias, School of Botany, The University of Melbourne, Parkville, Victoria, Australia
Published New York : Humana Press, [2013]


Location Call no. Vol. Availability
 W'PONDS  615.321 Roe/Mtf  AVAILABLE
Description x, 311 pages : illustrations (black and white, and colour) ; 26 cm
Series Methods in molecular biology, 1064-3745 ; 1055
Methods in molecular biology (Clifton, N.J.). 1064-3745 ; 1055
Contents Machine derived contents note: 1. Bryophytes: Liverworts, Mosses and Hornworts - Extraction and Isolation Procedures -- Yoshinori Asakawa and Agnieszka Ludwiczuk -- -- 2. Plant Tissue Extraction for Metabolomics -- Ute Roessner and Daniel Anthony Dias -- -- 3. Detection of Polar Metabolites through the use of Gas Chromatography - Mass Spectrometry -- David P. De Souza -- -- 4. A Robust GC-MS Method for the Quantitation of Fatty Acids in Biological Systems -- Nirupama Samanmalie Jayasinghe and Daniel Anthony Dias -- -- 5. A Workflow from Untargeted LC-MS Profiling to Targeted Natural Product Isolation -- Damien L. Callahan and Candace E. Elliot -- -- 6. Lipidomics -Extraction Protocols for Biological Matrices -- Thusitha Wasntha Thilanka Rupasinghe -- -- 7. Metabolite Analysis of Biological Fluids and Tissues by Proton Nuclear Magnetic Resonance Spectroscopy -- John Robert Sheedy -- -- 8. NMR Spectroscopy: Structure Elucidation of Cycloelatenene A: A Natural Product Case Study -- Sylvia Urban and Daniel Anthony Dias -- 9. NMR-Based Metabolomics: A Probe to Utilize Biodiversity -- Lúcia P. Santos Pimenta, Hye Kyong Kim, Robert Verpoorte, and Young Hae Choi -- -- 10. Extraction Protocol for Non-Targeted NMR and LC-MS Metabolomics-Based Analysis of Hard Coral and their Algal Symbionts -- Benjamin R. Gordon, William Leggat, and Cherie Motti -- -- 11. Determination of Absolute Configuration Using Single Crystal X-ray Diffraction -- Abigail L. Albright and Jonathan M. White -- -- 12. Natural Product Chemistry in Action: The Synthesis of Melatonin Metabolites K1 and K2 -- Helmut M. Hügel and Oliver A.H. Jones -- -- 13. Discovery, Biosynthesis, and Rational Engineering of Novel Enterocin and Wailupemycin Polyketide Analogues -- John A. Kalaitziz -- -- 14. Bioassays for Anticancer Activities -- Janice McCauley, Ana Zivanovic, and D. Skropeta -- -- 15. Screening for Anti-Diabetic Activities -- Rima Caccetta and Hani Al Salami -- -- 16. Screening for Antibacterial, Antifungal and Anti-Quorum Sensing Activity -- Elisa J. Hayhoe and Enzo A. Palombo -- -- 17. Metabolomics and Dereplication Strategies in Natural Products -- Ahmed Fares Tawfike, Christina Viegelmann, and RuAngelie Edrada-Ebel -- -- 18. Bridging the Gap: Basic Metabolomics Methods for Natural Product Chemistry -- Oliver A.H. Jones and Helmut M. Hügel -- -- 19. Strategies in Biomarker Discovery. Peak Annotation by MS and Targeted LC-MS Micro-Fractionation for de novo Structure Identification by Micro-NMR -- Philippe J. Eugster, Gaëtan Glauser, and Jean-Luc Wolfender -- -- 20. Statistical Analysis of Metabolomics Data -- Alysha M. De Livera, Moshe Olshansky, and Terence P. Speed
Summary A summary of recent developments occurring in natural product chemistry, which is transitioning to modern day metabolomics as a result of the advent of comprehensive analytical platforms and sensitive analytical instrumentation. This book seeks to serve both professionals and research students with its well-honed methodologies for natural product isolation, biomrker discovery, dereplication, biological assays and comprehensive metabolomic platforms available for high-throughput analyses
Analysis Australian
Notes "ISSN 1940-6029 (electronic)"--title page verso
Bibliography Includes bibliographical references and index
Notes Also available online. Publisher description:
Subject Biological assay.
Data mining -- Laboratory manuals.
Metabolites -- Laboratory manuals.
Natural products -- Laboratory manuals.
Natural products -- Analysis.
Metabolites -- Analysis.
Biological Products -- isolation & purification.
Biological Products -- pharmacology.
Metabolomics -- methods.
Metabolomics -- methods.
Genre/Form Laboratory Manual.
Laboratory manuals.
Author Dias, Daniel Anthony, editor of compilation
Roessner, Ute, editor of compilation
University of Melbourne. School of Botany.
LC no. 2013945168
ISBN 9781627035767 (hardback)