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Title Mass spectrometry in drug metabolism and disposition : basic principles and applications / edited by Mike S. Lee, Mingshe Zhu
Published Hoboken, N.J. : Wiley, [2011]
©2011
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Description 1 online resource
Series Wiley series on pharmaceutical science and biotechnology: practices, applications and methods
Contents Frontmatter -- Basic Concepts of Drug Metabolism and Disposition. Progression of Drug Metabolism / Ronald E White -- Common Biotransformation Reactions / Bo Wen, Sidney D Nelson -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry / Amit S Kalgutkar -- Drug-Metabolizing Enzymes, Transporters, and Drug-Drug Interactions / Steven W Louie, Magang Shou -- Experimental Models of Drug Metabolism and Disposition / Gang Luo, Chuang Lu, Xinxin Ding, Donglu Zhang -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery / Takehito Yamamoto, Hiroshi Suzuki, Akihiro Hisaka -- Drug Metabolism Research as Integral Part of Drug Discovery and Development Processes / W Griffith Humphreys -- Mass Spectrometry in Drug Metabolism: Principles and Common Practice. Theory and Instrumentation of Mass Spectrometry / Girard Hopfgartner -- Common Liquid Chromatography Mass Spectrometry (LCMS) Methodology for Metabolite Identification / Lin Xu, Lewis J Klunk, Chandra Prakash -- Mass Spectral Interpretation / Li-Kang Zhang, Birendra N Pramanik -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography, and Non-Mass-Spectrometric Detection / Mark Hayward, Maria D Bacolod, Qing Ping Han, Manuel Cajina, Zack Zou -- Applications of New LCMS Techniques in Drug Metabolism and Disposition. Quantitative in Vitro ADME Assays Using LCMS as a Part of Early Drug Metabolism Screening / Walter Korfmacher -- High-Resolution Mass Spectrometry and Drug Metabolite Identification / Russell J Mortishire-Smith, Haiying Zhang, Kevin P Bateman -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging / Richard F Reich, Daniel P Magparangalan, Timothy J Garrett, Richard A Yost -- Use of Triple Quadrupole Linear Ion Trap Mass Spectrometry as a Single LCMS Platform in Drug Metabolism and Pharmacokinetics Studies / Wenying Jian, Ming Yao, Bo Wen, Elliott B Jones, Mingshe Zhu -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry / John S Vogel, Peter Lohstroh, Brad Keck, Stephen R Dueker -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions / Jing-Tao Wu -- Profiling and Characterization of Herbal Medicine and its Metabolites Using LCMS / Zeper Abliz, Ruiping Zhang, Ping Geng, Dongmei Dai, Jiuming He, Jian Liu -- Liquid Chromatography Mass Spectrometry Bioanalysis of Protein Therapeutics and Biomarkers in Biological Matrices / Fumin Li, Qin C Ji -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress / Stacy L Gelhaus, Ian A Blair -- LC²́⁶MS in Endogenous Metabolite Profiling and Small-Molecule Biomarker Discovery / Michael D Reily, Petia Shipkova, Serhiy Hnatyshyn -- Appendix -- Index
(Publisher-supplied data) Part I Basic Concepts of Drug Metabolism and Disposition -- The Progression of Drug Metabolism -- Common Biotransformation Reactions -- Metabolic Activation of Organic Functional Groups Utilized in Medicinal Chemistry -- Drug Metabolizing Enzymes, Transporters and Drug-Drug Interactions -- Experimental Models of Drug Metabolism and Disposition -- Principles of Pharmacokinetics: Predicting Human Pharmacokinetics -- Drug Metabolism Research as an Integral Part of the Drug Discovery and Development Processes -- Part II Mass Spectrometry in Drug Metabolism: Principles and Common Practice -- Theory and Instrumentation of Mass Spectrometry -- Common Liquid Chromatography-Mass Spectrometry (LC-MS) Methodology for Metabolite Identification -- Mass Spectral Interpretation -- Techniques to Facilitate the Performance of Mass Spectrometry: Sample Preparation, Liquid Chromatography and Non-Mass Spectrometric Detection -- Part III Applications of New LC/MS Techniques in Drug Metabolism and Disposition -- Quantitative In Vitro ADME Assays using LC-MS as a Part of Early Drug Metabolism Screening -- High Resolution Mass Spectrometry and Drug Metabolite Identification -- Distribution Studies of Drugs and Metabolites in Tissue by Mass Spectrometric Imaging -- Use of Triple Quadrupole-Linear Ion Trap Mass Spectrometry as a Single LC/MS Platform in Drug Metabolism and Pharmacokinetics Studies -- Quantitative Drug Metabolism with Accelerator Mass Spectrometry -- Standard-Free Estimation of Metabolite Levels Using Nanospray Mass Spectrometry: Current Statutes and Future Directions -- Profiling and Characterization of Herbal Medicine and their Metabolites using LC-MS -- Liquid Chromatography Mass Spectrometry Bioanalysis of Proteins in Biological Matrices -- Mass Spectrometry in the Analysis of DNA, Protein, Peptide, and Lipid Biomarkers of Oxidative Stress -- LC-MS in Endogenous Metabolite Profiling and Small Molecule Biomarker Discovery
Summary "This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text"--Provided by publisher
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Drugs -- Metabolism -- Analysis.
Mass spectrometry.
Metabolites -- Spectra.
Biopharmaceutics -- methods.
Drug Design.
Mass Spectrometry -- methods.
Pharmaceutical Preparations -- metabolism.
Pharmacokinetics.
Form Electronic book
Author Lee, Mike S., 1960-
Zhu, Mingshe.
ISBN 047092926X (electronic bk.)
0470929278 (electronic bk.)
9780470929261 (electronic bk.)
9780470929278 (electronic bk.)