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Title Mesenchymal stromal cells : biology and clinical applications / Peiman Hematti, Armand Keating, editors
Published New York, NY : Humana Press, ©2013


Description 1 online resource
Series Stem cell biology and regenerative medicine
Stem cell biology and regenerative medicine.
Contents Basic Biology -- Mesenchymal Stromal Cells in Regenerative Medicine: A Perspective / Peiman Hematti, Armand Keating -- MSCs: Changing Hypotheses, Paradigms, and Controversies on Mechanisms of Action in Repairing Tissues / Darwin J. Prockop, Roxanne L. Reger -- MSCs: The Need to Rethink / Paolo Bianco, Pamela G. Robey -- Characterization of MSCs: From Early Studies to the Present / Mark F. Pittenger -- MSCs as Therapeutics / Arnold I. Caplan -- MSC Niche for Hematopoiesis / Daniel Lucas, Sandra Pinho, Paul S. Frenette -- Immunomodulatory Properties of MSCs / Maria Ester Bernardo, Lynne M. Ball, Franco Locatelli, -- MSCs and Innate Immune Responses: A Balancing Act / Krisztián Németh, Éva Mezey, -- MSCs: Paracrine Effects / Siddiraju V. Boregowda, Donald G. Phinney -- Cross-Talk Between MSCs and Their Environments / Thomas P. Lozito, Rocky S. Tuan
Human MSCs from Bone Marrow, Umbilical Cord Blood, and Adipose Tissue: All the Same? / Patrick Wuchter, Anthony D. Ho -- MSCs in Solid Tumors and Hematological Malignancies: From Basic Biology to Therapeutic Applications / Rodrigo Jacamo, Erika Spaeth, Venkata Battula, Frank Marini -- MSC Studies in Large-Animal Models / Bruce A. Bunnell, Christine Gagliardi, Maria Isabel Ribeiro Dias -- Defining the Potential of MSCs with a Prenatal Large Animal Model / Graça Almeida-Porada, Christopher D. Porada, Esmail D. Zanjani -- From Bench to Bedside -- Bench-to-Bedside Development of MSC Therapies: A Multidisciplinary Approach / Sowmya Viswanathan, Elizabeth J. Read -- cGMP Production of MSCs / Derek J. Hei, David H. McKenna Jr. -- MSCs: The US Regulatory Perspective / Adrian P. Gee -- MSCs: Clinical Applications and European Regulatory Aspects / Jens Reinhardt, Egbert Flory, Isabel Büttel, Christa Schröder, Stefan Fricke
Stem Cell Treatments Around the World: Boon or Bane? / Alok Srivastava -- Safety Issues in MSC Therapy / Minoo Battiwalla, A. John Barrett -- In Vivo Imaging of MSCs / Jeff W.M. Bulte -- National Heart, Lung, and Blood Institute Support of Cellular Therapies Regenerative Medicine / Traci Heath Mondoro, John Thomas -- Clinical Applications -- MSC Therapy of Inborn Errors / Edwin M. Horwitz, -- MSCs for Enhancement of Hematopoietic Progenitor Cell Engraftment and Poor Graft Function / Paolo F. Caimi, Hillard M. Lazarus -- MSCs for Graft-Versus-Host Disease / Jakub Tolar, Katarina Le Blanc, Bruce R. Blazar -- MSCs in Pediatric Hematopoietic Stem Cell Transplantation / Lynne M. Ball, Maria Ester Bernardo, -- MSC for Ex Vivo Expansion of Umbilical Cord Blood Cells / Ian K. McNiece, Simon N. Robinson, Elizabeth J. Shpall -- MSCs for Autoimmune Diseases / Alan Tyndall, Chiara Bocelli
MSCs for Induction of Solid Organ Allograft Acceptance / Marc Dahlke, Philipp Renner, Elke Eggenhofer -- MSCs for Gastrointestinal Disorders / Maria Ester Bernardo, Angela Maria Cometa -- MSCs for Cardiac Repair / Amish N. Raval, Timothy A. Hacker -- MSCs for Treatment of Acute Lung Injury / Vladimir B. Serikov, Anna Krasnodembskaya, Jae Woo Lee -- MSCs for Diabetes / Luca Inverardi, Giacomo Lanzoni, Juan Dominguez-Bendala, Camillo Ricordi -- MSCs for Renal Repair / Anna M. Gooch, Christof Westenfelder -- MSCs for the Treatment of Stroke, Spinal Cord Injury, and Traumatic Brain Injury: From Bench Work to Clinical Trials / Bing Yang, Ramy El Khoury, Sean I. Savitz -- MSCs in Reconstructive Surgery / Summer E. Hanson, Michael L. Bentz -- MSCs in Orthopedic Surgery / Summer E. Hanson, Nicholas H. Maassen -- Adipose Tissue-Derived MSCs: Moving to the Clinic / Pedro P. Carvalho, Manuela E. Gomes
Summary Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include:Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regenerationIdentifying the potential of MSCs in proceeding from bench to bedside from regulatory, GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues
Analysis Life sciences
Stem cells
Cell Biology
Bibliography Cludes bibliographical references
Subject Mesenchymal stem cells.
Cellular therapy.
Mesenchymal Stem Cells -- physiology
Cell- and Tissue-Based Therapy
Mesenchymal Stem Cell Transplantation
Mesenchymal Stem Cells
MEDICAL -- Research.
Cellular therapy
Mesenchymal stem cells
Form Electronic book
Author Hematti, Peiman
Keating, Armand.
ISBN 9781461457114