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Title Stem cell-dependent therapies : mesenchymal stem cells in chronic inflammatory disorders / edited by Gerhard Gross and Thomas Häupl
Published Berlin : De Gruyter, [2013]


Description 1 online resource (xviii, 408 pages .)
Contents Preface; Contributing authors; 1 Mesenchymal stem cells in the context of stem cell biology; 1.1 Introduction -- Definitions; 1.2 Embryonic and adult tissue stem cells; 1.3 Adult tissue stem cells and progenitors; 1.4 Adult stem cells and tissue homeostasis; 1.5 Adult stem cell niches; 1.6 Commitment and differentiation; 1.7 The case for bone marrow MSCs; 1.8 Clinical prospects; 1.9 Concluding remark; References; 2 Are mesenchymal stem cells immune privileged?; 2.1 Introduction -- Definition of mesenchymal stem cells (MSCs); 2.2 The immunosuppressive effect of MSCs on immune cells
2.3 The potential clinical benefits of MSCs as immunosuppressants2.4 The mechanisms of immunosuppression by MSCs; 2.5 The mechanisms of immunosuppression by human MSCs; 2.6 Immunosuppression by murine MSCs and the species difference underlying the mechanisms of immunosuppression by MSCs; 2.7 Immunosuppression mediated by fibroblasts; 2.8 The mechanisms of the immunosuppressive effect of MSCs are shared with other nonstromal cells; 2.9 How long can MSCs survive in vivo?; 2.10 Conclusion and discussion; References; 3 Mesenchymal stem cell therapies for autoimmune diseases; 3.1 Introduction
3.2 Autoimmune disease3.3 Mesenchymal stem cells (MSCs); 3.3.1 Animal models; 3.4 Results of MSCs clinical trials; 3.5 Safety of MSCs; 3.6 Conclusion; References; 4 Mesenchymal stem cells in osteoarthritis and rheumatic disease; 4.1 Introduction -- Rheumatic diseases; 4.2 Rheumatoid arthritis (RA); 4.3 Osteoarthritis (OA); 4.4 MSCs in healthy and rheumatic joint tissues; 4.5 Application of MSCs in rheumatic diseases; 4.6 MSCs application in animals; 4.7 Clinical studies in humans; 4.8 Risks and benefits of MSCs treatments in rheumatic diseases; References
5 Mesenchymal stem cells in enthesis formation and repair5.1 Introduction; 5.2 Structure of the tendon-to-bone junction; 5.3 Enthesis resident T cells are involved in enthesopathies provoking inflammation and bone remodeling; 5.4 Biomaterials and growth factor-dependent regeneration of tendon-to-bone junctions; 5.5 Biomechanical stimulation for enthesis repair; 5.6 Mesenchymal stem cells (MSCs); 5.7 Stem cell-dependent approaches for repair of osteotendinous junctions; 5.8 Stem cell-dependent delivery of growth factors; 5.9 Stem cell-dependent delivery of tenogenic transcription factors
5.10 Stem cell-dependent delivery of matrix metalloproteinases5.11 Trophic activities of MSCs in enthesis repair; 5.12 Outlook; Acknowledgment; References; 6 Mesenchymal stem cells for clinical/therapeutic interventions of graft-versus-host disease; 6.1 Clinical graft-versus-host disease; 6.2 Chronic graft-versus-host disease; 6.3 Rationale to use mesenchymal stromal cells for treatment of GvHD; 6.4 Experience of MSCs in clinical acute graft-versus-host disease
Summary This book investigates the current state of the MSC-dependent therapy of chronic inflammatory disorders and autoimmune diseases. Among the covered topics are GvHD, chronic kidney, liver and lung disease, ischemic heart and inflammatory bowel disease, diabetes, osteoarthritis, various rheumatic and neurological disorders, tumors and solid organ transplantations
Bibliography Includes bibliographical references and index
Notes In English
Print version record
Subject Mesenchymal stem cells -- Transplantation
Chronic diseases -- Treatment
Inflammation -- Immunological aspects.
Inflammation -- Treatment
Mesenchymal Stromal Cells
Mesenchymal Stem Cell Transplantation
Chronic Disease -- therapy
Inflammation -- immunology
Inflammation -- therapy
Mesenchymal Stem Cells -- immunology
HEALTH & FITNESS -- Diseases -- General.
MEDICAL -- Clinical Medicine.
MEDICAL -- Diseases.
MEDICAL -- Evidence-Based Medicine.
MEDICAL -- Internal Medicine.
Chronic diseases -- Treatment
Inflammation -- Immunological aspects
Form Electronic book
Author Gross, Gerhard, 1949- editor.
Häupl, Thomas, editor
ISBN 3110298309