Drug-Membrane Interactions; Contents; Preface; Foreword; Introduction; 1 Function, Composition, and Organization of Membranes; 2 Octanol-Water Partitioning versus Partitioning into Membranes; 3 Analytical Tools for the Analysis and Quantification of Drug-Membrane Interactions; 4 Drug-Membrane Interaction and Pharmacokinetics of Drugs; 5 Drug-Membrane Interactions and Pharmacodynamics; 6 Computer Simulation of Phospholipids and Drug-Phospholipid Interactions; Index
Summary
Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effect
